Publications by authors named "Bruno Giovanni Galuzzi"
Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn's disease and ulcerative colitis, are multifactorial disorders characterized by chronic inflammation of the gastrointestinal tract. On the other hand, IBS is one of the principal gastrointestinal tract functional disorders and is characterized by abdominal pain and altered bowel habits.
View Article and Find Full Text PDFDetermining the redox potentials of protein cofactors and how they are influenced by their molecular neighborhoods is essential for basic research and many biotechnological applications, from biosensors and biocatalysis to bioremediation and bioelectronics. The laborious determination of redox potential with current experimental technologies pushes forward the need for computational approaches that can reliably predict it. Although current computational approaches based on quantum and molecular mechanics are accurate, their large computational costs hinder their usage.
View Article and Find Full Text PDFArticle Synopsis
- Metabolism is regulated through complex mechanisms that involve both enzyme expression levels and interactions with metabolites, affecting the reaction rates in metabolic pathways.
- High-throughput data from metabolomics and transcriptomics need to be integrated to properly understand these regulatory interactions, as analyzing them separately fails to capture their interdependencies.
- The proposed INTEGRATE computational pipeline combines these data types using metabolic models, helping to distinguish how different regulatory layers affect metabolic fluxes, with practical applications in personalized cancer therapies.