Publications by authors named "Bruno Elias Luna"
Article Synopsis
- Bovine trichomonosis (BT) is a disease caused by the protozoan Tritrichomonas foetus, leading to infertility and economic losses in cattle due to its effects on the urogenital tract.
- Researchers isolated and performed proteomic profiling on six Tf isolates, identifying 662 proteins, with 121 common across all isolates and significant portions being uncharacterized.
- Immunoassays demonstrated the antigenic potential of the supernatant proteins, notably highlighting Grp78 and Ap65, potentially aiding in developing new diagnostics and treatments for BT.
Bovine Trichomonosis, an endemic sexually transmitted disease in countries with extensive livestock and natural service, represents one of the most common causes of reproductive failure. 5-nitroimidazoles and their derivatives are used for its treatment, mainly metronidazole (Mz). The emergence of resistance mechanisms adopted by the parasites against the drug and failure of the treatments suggest the need to investigate susceptibility and obtain current values.
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- Tritrichomonas foetus is the cause of Bovine Trichomonosis (BT), a significant health issue in Argentina that leads to reproductive problems and economic losses for cattle farmers.
- Metronidazole, the main treatment for BT, only offers temporary relief and is becoming less effective due to increasing drug resistance both in laboratory and real-world settings.
- This study examines the susceptibility of six T. foetus isolates under different oxygen conditions, revealing higher resistance levels than previously documented, and aims to inform better treatment strategies in Argentina.