Publications by authors named "Bruno Cesar da Silva"
DIAGNOSIS AND TREATMENT OF MICROSCOPIC COLITIS: POSITION PAPER ON BEHALF OF THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY.
Arq Gastroenterol
January 2025
Background: Microscopic colitis (MC) is a chronic inflammatory condition of the colon, primarily characterized by watery diarrhea, with normal or near-normal endoscopic findings. It encompasses two main subtypes: lymphocytic colitis and collagenous colitis.
Objective: This position paper from the Brazilian Federation of Gastroenterology aims to review current evidence on the diagnosis and management of MC in Brazil, emphasizing the need for standardization across the country's healthcare systems.
Background And Aims: This systematic review aims to elucidate the use of corticosteroids in randomized clinical trials (RCTs) evaluating biologics and small molecules for inflammatory bowel disease (IBD). We analyzed corticosteroid use during both the induction and maintenance phases, highlighting areas needing standardization and improvement in clinical research.
Methods: We selected placebo-controlled phase 3 RCTs involving adults with moderate to severe IBD.
Corticosteroid-Free Remission in Patients With Inflammatory Bowel Disease.
Gastroenterol Hepatol (N Y)
March 2024
The metastable wurtzite crystal phase in gallium phosphide (WZ GaP) is a relatively new structure with little available information about its emission properties compared to the most stable zinc-blend phase. Here, the effect of growth conditions of WZ GaP nano- and microstructures obtained via chemical beam epitaxy on the optical properties was studied using power- and temperature-dependent photoluminescence (PL). We showed that the PL spectra are dominated by two strong broad emission bands at 1.
View Article and Find Full Text PDFA key issue in the development of high-performance semiconductor devices is the ability to properly measure active dopants at the nanometer scale. In a p-n junction, the abruptness of the dopant profile around the metallurgical junction directly influences the electric field. Here, a contacted nominally symmetric and highly doped ( = = 9 × 10 cm) silicon p-n specimen is studied through in situ biased four-dimensional scanning transmission electron microscopy (4D-STEM).
View Article and Find Full Text PDFINFLAMMATORY BOWEL DISEASE CARE IN BRAZIL: HOW IT IS PERFORMED, OBSTACLES AND DEMANDS FROM THE PHYSICIANS' PERSPECTIVE.
Arq Gastroenterol
February 2021
Article Synopsis
- Inflammatory bowel diseases (IBD) are increasingly common chronic conditions in Brazil that significantly affect patients' health and quality of life over time.
- A study surveyed 286 physicians, primarily gastroenterologists and colorectal surgeons, about their experiences and challenges in treating IBD in various Brazilian regions.
- Key findings indicated difficulties in accessing medications and performing specialized procedures, with the most prescribed treatments being biological medications like infliximab and adalimumab, while discussions about therapy failures and new treatments were highlighted as priorities for healthcare conferences.
Introduction: The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy.
Methods: In this cross-sectional study UC patients were interviewed, and additional information was collected from the medical records. Descriptive statistics and multivariate Poisson regression analysis were used.
Article Synopsis
- Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon and rectum, primarily presenting with bloody diarrhea and characterized by periods of flare-ups and remission.
- The incidence of UC has risen globally, especially in developing countries, while advances in treatment have improved life expectancy and reduced mortality rates.
- Variability in how UC manifests means that certain patient characteristics can indicate more severe cases, prompting the need for closer monitoring and stronger treatment options for those at higher risk.
Introduction: This study evaluated the performance of an in-house nested-PCR system for the detection of the Mycobacterium tuberculosis complex in pleural fluid, blood and urine samples from pleural effusion tuberculosis patients by health services physicians in Pernambuco, Brazil.
Methods: A prospective double-blind study with 37 hospitalized patients of both sexes, aged over 15, was used to investigate the diagnosis of pleural effusion. The criteria used to define the cases included the demonstration of bacillus in biological samples by smear or culture or by a granulomatous finding in the histopathological examination, associated with an evident response to specific treatments to each clinical situation.