Background: There is no consistent framework for patient-centric drug product design, despite the common understanding that drug product acceptability and preferences influence adherence and, therefore, drug product effectiveness. The aim of this review was to assess current understanding of patient acceptability and preferences for solid oral dosage form (SODF) drug product attributes, and the potential impact of these attributes on patient behaviors and outcomes.
Patients And Methods: A scoping review was conducted.
The performance of pharmaceutical dosage forms relies heavily on the characteristics of the excipients that are incorporated into the drug product during the manufacturing process. Therefore, it is imperative that formulators are able to accurately and completely specify the key chemical and physical properties of those excipients. Current approaches to describing excipients are outdated and inadequate for the needs of the 21 century and in this article we highlight the benefits of a more systematic and comprehensive approach to specifying and controlling excipient properties.
View Article and Find Full Text PDFMultiparticulate formulations allow for the design of specialized pharmaceutical dosage forms that cater to the needs of a wide range of patient demographics, such as pediatric and geriatric populations, by affording control over the release rate and facilitating the formulation of fixed-dose combination drugs. Melt spray-congealing (MSC) is a method for preparing multiparticulate dosage forms from a suspension or solid solution of active pharamaceutical ingredients (API) and a molten carrier matrix. Stearyl alcohol and poloxamer 407 mixtures are widely used as carrier matrices in MSC microsphere formulations.
View Article and Find Full Text PDFJ Pharm Sci
January 2019
Data from wall friction testing and physical property characterization of over 100 pharmaceutical powders, blends, and granulations have been analyzed. The analyses focused on data for stainless steel surfaces with the most common finishes for pharmaceutical powder processing equipment, either a 2B cold rolled mill finish or an electropolished 2B surface. Active pharmaceutical ingredients exhibited the highest friction against these surfaces, whereas active granulations exhibited the least friction.
View Article and Find Full Text PDFPredicting the crystallization propensity of drug-like molecules is one of the most significant challenges facing pharmaceutical scientists today. Despite the importance of being able to understand what structural features of a molecule (polarity, molecular size, etc.) and which experimental conditions (temperature, concentration, etc.
View Article and Find Full Text PDFElectrostatic charging via contact electrification or tribocharging refers to the process of charge transfer between two solid surfaces when they are brought into contact with each other and separated. Charging of continuous particulate flows on solid surfaces is poorly understood and has often been empirical. This study aims toward understanding the tribocharging of pharmaceutical excipients using a simplified geometry of unidirectional flow in a hopper-chute assembly.
View Article and Find Full Text PDFThe mechanical properties of a solid dosage, defined by its granular micro-structure and geometry, play a key role in its dissolution profile and performance. An ultrasonic method for extracting the viscoelastic material properties and granular structure of drug tablet compacts is introduced and its utility is demonstrated for tablet compacts made of microcrystalline cellulose (MCC), lactose monohydrate, and sodium starch glycolate as well as magnesium stearate as lubricant. The approach is based on the effect of viscoelasticity and internal micro-structures on the frequency-dependent attenuation of an ultrasonic wave propagating in a granular medium.
View Article and Find Full Text PDFResponses from the second Product Quality Research Institute (PQRI) Blend Uniformity Working Group (BUWG) survey of industry have been reanalyzed to identify potential links between formulation and processing variables and the measured uniformity of blends and unit dosage forms. As expected, the variability of the blend potency and tablet potency data increased with a decrease in the loading of the active pharmaceutical ingredient (API). There was also an inverse relationship between the nominal strength of the unit dose and the blend uniformity data.
View Article and Find Full Text PDFThe mechanical properties of a drug tablet can affect its performance (e.g., dissolution profile and its physical robustness.
View Article and Find Full Text PDFPhys Rev E Stat Nonlin Soft Matter Phys
August 2011
We analyze the scaling properties of the Hertz-Kuwabara-Kono (HKK) model, which is commonly used in numerical simulations to describe the collision of macroscopic noncohesive viscoelastic spherical particles. Parameters describing the elastic and viscous properties of the material, its density, and the size of the colliding particles affect the restitution coefficient ɛ and collision time τ only via appropriate rescaling but do not change the shape of ɛ(v) and τ(v) curves, where v is the impact velocity. We have measured the restitution coefficient experimentally for relatively large (1 cm) particles of microcrystalline cellulose to deduce material parameters and then to predict collision properties for smaller microcrystalline cellulose (MCC) particles by assuming the scaling properties of the HKK model.
View Article and Find Full Text PDFAn ultrasonic non-destructive technique for the microstructure length-scale characterization of solid dosage pharmaceutical tablets is presented. The technique is based on the relationship between the attenuation of longitudinal ultrasonic elastic waves and the size of micro-structural features in the tablet material. In the reported experiments, the ultrasonic attenuation in microcrystalline cellulose (MCC)-lactose monohydrate (LMH) blended pharmaceutical compacts is measured by means of two pitch-catch experiments.
View Article and Find Full Text PDFDiscrete element model (DEM) simulations of the discharge of powders from hoppers under gravity were analyzed to provide estimates of dosage form content uniformity during the manufacture of solid dosage forms (tablets and capsules). For a system that exhibits moderate segregation the effects of sample size, number, and location within the batch were determined. The various sampling approaches were compared to current best-practices for sampling described in the Product Quality Research Institute (PQRI) Blend Uniformity Working Group (BUWG) guidelines.
View Article and Find Full Text PDFWhen tablets collide during manufacturing and handling operations they rebound with a force and velocity that is determined by the collision conditions and the properties of the materials. This collision-rebound behavior of solid bodies can be described using a parameter known as the "coefficient of restitution" (CoR). In this work, the CoR of a range of pharmaceutical tablets/compacts is measured using a simple "drop test", and the influences of material properties (elastic modulus, solid fraction, etc.
View Article and Find Full Text PDFAssessing particle mechanical properties of pharmaceutical materials quickly and with little material can be very important to early stages of pharmaceutical research. In this study, a wide range of pharmaceutical materials were studied using atomic force microscopy (AFM) nanoindentation. A significant amount of particle hardness and elastic modulus data were provided.
View Article and Find Full Text PDFExperiments have been conducted to measure the coefficient of rolling resistance (CoRR) of some pharmaceutical tablets and several common materials, such as glass beads and steel ball bearings. CoRR values are required as inputs for discrete element method (DEM) models which can be used to model particulate flows and solid dosage form manufacturing processes. Until now there have been no CoRR data reported for pharmaceutical materials, and thus these new data will help to facilitate more accurate modeling of pharmaceutical systems.
View Article and Find Full Text PDFThe kinetic (or sliding) friction of pharmaceutical tablets and capsules influences how they will behave during the conveying, coating, and packaging operations that are used for drug product manufacturing. In order to logically design equipment for manufacturing and packaging operations, and to simulate manufacturing and packaging performance (for example, using discrete or finite element modeling approaches), it is necessary to quantify the magnitude of the kinetic friction. In this work, the coefficient of kinetic friction of a range of pharmaceutical tablets and capsules has been measured for the first time using a pin-on-disk tribometer.
View Article and Find Full Text PDFRefractive index is a basic physical property of pharmaceutical solids. In this paper, the refractive index values of 424 pharmaceutical solids from the literature were surveyed. It was found that the refractive index values exhibit a normal distribution with an overall mean value of 1.
View Article and Find Full Text PDFThe capability of the newly developed dynamic image analysis instrument QicPic equipped with the high-speed dry-powder-dispersing device was investigated systematically using various MCC particles. Instrument cross-validation was conducted by comparing the particle size distribution of spherical particles obtained with the QicPic and with a conventional laser diffraction instrument (HELOS). While good agreement was observed with spherical particles, significant differences were found when analyzing rod-shaped Ceolus KG-1000 particles, revealing the intrinsic difference in operating principles between these two techniques.
View Article and Find Full Text PDFThe discrete element method (DEM) is widely used to model a range of processes across many industries. This paper reviews current DEM models for several common pharmaceutical processes including material transport and storage, blending, granulation, milling, compression, and film coating. The studies described in this review yielded interesting results that provided insight into the effects of various material properties and operating conditions on pharmaceutical processes.
View Article and Find Full Text PDFTrue density is a fundamental and important property of active pharmaceutical ingredients (APIs). Using prediction methods to estimate the API true density can be very beneficial in pharmaceutical research and development, especially when experimental measurements cannot be made due to lack of material or sample handling restrictions. In this paper, two empirical prediction methods developed by Girolami and Immirzi and Perini were used to estimate the true density of APIs, and the estimation results were compared with experimentally measured values by helium pycnometry.
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