Publications by authors named "Bruno A B de Andrade"
Introduction: Leukemia and lymphoma mimicking periapical conditions can lead to significant diagnostic pitfalls. Guidance for endodontists in managing such cases is barely explored. This systematic review aimed to summarize the clinicopathologic, imaging, and management aspects of leukemia/lymphoma that mimicked periapical conditions and resulted in endodontic treatment.
View Article and Find Full Text PDFBackground: Some odontogenic cysts (OCs) and odontogenic tumors (OTs) are infiltrative and often recur, causing bone destruction and tooth loss. In the elderly, in particular, these injuries cause significant morbidity, making rehabilitation difficult and compromising the quality of life of these individuals. Objective: To determine the prevalence and demographic characteristics of OCs, non-odontogenic cysts (NOCs), and OTs diagnosed in an elderly Brazilian population (≥60 years).
View Article and Find Full Text PDFObjective: This systematic review aimed to verify if individuals with thalassemia present changes in radiomorphometric indices and fractal analysis that can be accessed using panoramic radiographs.
Material And Methods: Observational studies that evaluated cortical and trabecular bone patterns in dental routine radiographs were selected from six bibliographic databases. Risk of bias was analyzed using the Joanna Briggs Institute Critical Appraisal Checklists.
Main oral characteristics and treatment of ligneous gingivitis and periodontitis in individuals with plasminogen deficiency: A systematic review.
Spec Care Dentist
December 2024
Article Synopsis
- This systematic review focused on the characteristics and treatment of ligneous gingivitis (LG) and periodontitis (LP) in patients with plasminogen deficiency (PD), analyzing 17 case reports related to these oral conditions.
- The findings revealed that 56% of patients had type I PD, with common symptoms including ulceration and bone loss, and the most frequent treatment was conventional periodontal scaling.
- Limitations in current research create challenges in diagnosing and treating LG/LP, highlighting the need for more comprehensive future studies with detailed treatment descriptions and longer follow-up periods.
The life course approach scrutinizes factors that shape the development of diseases over time. Tooth loss, which is influenced by social, behavioral and biological factors, can occur at various stages of life and tends to become more prevalent in later years. This systematic review examined the influence of socioeconomic, psychosocial, biological and behavioral adversities in life on the likelihood of tooth loss.
View Article and Find Full Text PDFObjective: To investigate Treponema pallidum detection using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) assays in acquired oral syphilis (AOS).
Materials And Methods: Thirty-seven paraffin-embedded tissue specimens of AOS (32 secondary and five primary) were analyzed, integrating double-positive serological results with clinicodemographic and histopathological data. T.
The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible.
View Article and Find Full Text PDFHistiocytic sarcoma affecting the oral cavity: a clinical, pathologic and molecular study.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Objective: To investigate the clinicopathological, immunohistochemical and molecular features of histiocytic sarcomas affecting the oral cavity.
Methods: Pathology files of two institutions were searched for cases of histiocytic sarcoma, and new H&E-stained slides and immunohistochemistry reactions evaluated for diagnosis confirmation. Molecular screening for KRAS and PIK3CA mutations was performed through polymerase chain reaction (PCR) followed by Sanger sequencing.
Purpose: This study aims to report clinicopathologic and imaging features of odontogenic myxomas (OM), highlighting uncommon findings.
Methods: Clinicopathologic and imaging data of OMs diagnosed in the five Brazilian diagnostic pathology centers were collected and analyzed.
Results: The series comprised 42 females (68.
Article Synopsis
- Granular Cell Tumor (GCT) is a rare benign oral lesion, often misdiagnosed due to its similarity to other conditions, highlighting the need for more awareness on its prevalence and characteristics.
- A study at six diagnostic centers in Brazil and Argentina analyzed 61 GCT cases, predominantly in females (73.8%), with most tumors on the tongue, presenting as painless nodules or papules in various colors and sizes.
- Histopathological analysis revealed distinctive cell characteristics, with low agreement between clinical and histological diagnoses, but no local recurrences were noted during the follow-up period.
Background: Uremic stomatitis is often unfamiliar to healthcare professionals. This study presents five cases of uremic stomatitis, providing a comprehensive analysis of their demographic distribution, clinicopathological features, and management strategies based on existing literature.
Methods: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico.
Oral Lesions of Immune-Mediated and Autoimmune Diseases: A 12-year Experience at a Single Brazilian Referral Center.
Head Neck Pathol
June 2024
Article Synopsis
- A study in Brazil examined the occurrence and characteristics of oral lesions linked to immune-mediated and autoimmune diseases in patients over a twelve-year period.
- Out of 3,790 lesions diagnosed, 160 (4.2%) were related to such diseases, mainly affecting middle-aged women, with oral lichen planus, mucous membrane pemphigoid, and pemphigus vulgaris being the most common types.
- The research highlighted that these lesions often cause pain and require a comprehensive, multidisciplinary approach for management and treatment, with varying times for disease stabilization depending on the condition.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is the most common non-Langerhans cell histiocytosis in children, primarily affecting the skin, especially on the head and neck.
- A case study highlights congenital JXG in a 5-month-old boy, who had a specific nodule above his left upper lip with unique histopathological features.
- The article emphasizes the need for clinicians to recognize the diverse presentations of JXG, particularly congenital cases, for effective treatment.
Article Synopsis
- - The study examines oral lesions in systemic lupus erythematosus (SLE) patients from Latin America, highlighting their varied characteristics and challenges in diagnosis, especially when lesions appear alone.
- - In a sample of 70 SLE patients, the majority were white females with an average age of 38.4 years, and the most common oral lesions were ulcers, erosions, and white lesions, often found in the hard/soft palate.
- - Findings suggest that unusual oral changes may signal underlying systemic issues, emphasizing the need for a multidisciplinary approach and regular oral exams to identify and treat these lesions effectively.
Conservative management of multiple odontogenic keratocysts in a child with nevoid basal cell carcinoma syndrome: A case report.
Spec Care Dentist
September 2024
Article Synopsis
- * A case study of an 11-year-old girl with NBCCS showed she had several OKCs, but her scans of the chest and brain were normal, and her dental structure indicated some jaw alignment issues.
- * The treatment involved a careful plan that included a combination of procedures to minimize surgery and the chance of the cysts returning, which proved successful as she showed no recurrence or new cysts over a 32-month follow-up.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign tumor that can mimic malignant conditions, often causing confusion among healthcare providers.
- A case involving a 2-month-old infant with an extensive 10 cm tumor protruding from the anterior maxilla and cheek is reported, which caused displacement of the nose.
- After surgical removal of the tumor, the patient showed no signs of recurrence during a 6-month follow-up, highlighting the need for early diagnosis and treatment for better outcomes.
The immunoexpression of BubR1 and cyclin B1 in pleomorphic adenoma (PA) and polymorphic adenocarcinoma (PAC) in minor salivary glands is poorly studied. Thus, a retrospective and observational study was performed to provide a better understanding of the role and immunopositivity patterns of these proteins in these lesions. Sixteen cases of PA and 16 cases of PAC were selected.
View Article and Find Full Text PDFBackground: This study aimed to investigate the clinicopathological features of metastases in the oral and maxillofacial regions.
Methods: In this retrospective study, biopsy records were obtained from referral centers for oral and maxillofacial diagnosis in Brazil, Guatemala, Mexico, and South Africa.
Results: A total of 120 cases were evaluated.
Squamous odontogenic tumor (SOT) is a rare benign but locally infiltrative tumor often misdiagnosed as other entities, such as ameloblastoma and squamous cell carcinoma, due to overlapping morphological findings. We document here the clinicopathological and imaging findings of an aggressive intraosseous SOT in the posterior left region of the maxilla in a 25-year-old male patient. On intraoral examination, the tumor extended from the region of the left lateral incisor to the upper left premolar and was covered by reddish mucosa, with discrete areas of ulceration.
View Article and Find Full Text PDFArticle Synopsis
- * Biopsies revealed specific cellular changes in both oral and skin lesions, consistent with trichilemmoma and fibroepithelial hyperplasia.
- * The case is an example of Cowden syndrome, a rare genetic disorder affecting multiple body systems, particularly involving the mouth and skin, with fewer than 40 documented cases in middle-aged adults.
Article Synopsis
- The study investigated the clinical and pathological characteristics of 19 oral solitary fibrous tumors (SFTs), revealing a predominance in females and an average patient age of 47.3 years.
- Most tumors were found in the buccal mucosa and appeared as asymptomatic nodules; over half exhibited a classic hybrid pattern in their cellular structure.
- All tumors tested positive for specific markers (STAT6 and CD34), and follow-up data indicated no local recurrence in the few patients tracked, underscoring the need for accurate diagnosis by pathologists to avoid misdiagnosis of these rare tumors.
Background: Dermal facial fillers are increasingly popular. Published reports on the clinical and histopathologic characteristics related to adverse reactions to dermal fillers in the facial region have been relatively well documented. This study adds to the literature on adverse reactions to injected filler in the oral and maxillofacial region in a South American population.
View Article and Find Full Text PDFClinical diagnostic approach for oral lymphomas: a multi-institutional, observational study based on 107 cases.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2023
Objective: To evaluate oral lymphomas' clinical manifestations and investigate whether clinical features are associated with lymphoma subtypes.
Study Design: Oral lymphomas with at least 1 representative clinical image were evaluated. They were classified according to their microscopic grade (high vs low), predominant cell size (small vs medium/large), and cellular lineage (B cell vs T cell).