Thermodynamic computing via autonomous quantum thermal machines.

We develop a physics-based model for classical computation based on autonomous quantum thermal machines. These machines consist of few interacting quantum bits (qubits) connected to several environments at different temperatures. Heat flows through the machine are here exploited for computing.

Cinnamic Acid and Caffeic Acid Effects on Gastric Tight Junction Proteins Analyzed in Oocytes.

Analysis of secondary plant compounds for the development of novel therapies is a common focus of experimental biomedicine. Currently, multiple health-supporting properties of plant-derived molecules are known but still information on many mechanisms is scarce. Cinnamic acid and caffeic acid are two of the most abundant polyphenols in human dietary fruits and vegetables.

Late presentation for hepatitis C treatment: prevalence and risk factors in the Swiss Hepatitis C Cohort.

Objective: Patients with 'late presentation' (LP) of chronic hepatitis C infection (HCV) have already developed advanced liver disease before receiving direct-acting antiviral (DAA) treatment. Even after successful treatment, the risk of morbidity and premature death remains elevated, leading to an unnecessary disease burden. This study aimed to assess the prevalence of LP within the prospective observational Swiss Hepatitis C Cohort (SCCS) and evaluate risk factors as determinants of LP.

Lotka-Volterra models for the market penetration of renewable energy.

We studied trend models for the energy and electricity markets and compared their complexity. Was it associated to the ease of policy interventions to control these markets? Using open data, we applied Lotka-Volterra type models to describe the evolution of the market shares of renewable energy and of electricity from renewable sources and observed that for the latter data more complex models were needed. We then searched for characteristics and anomalies in these models that might indicate immunity to and susceptibility for policy interventions towards reaching carbon neutrality, respectively.

Toward the Device-Independent Certification of a Quantum Memory.

Quantum memories represent one of the main ingredients of future quantum communication networks. Their certification is therefore a key challenge. Here we develop efficient certification methods for quantum memories.

Unlimited One-Way Steering.

This work explores the asymmetry of quantum steering in a setup using high-dimensional entanglement. We construct entangled states with the following properties: (i) one party (Bob) can never steer the state of the other party (Alice), considering the most general measurements, and (ii) Alice can strongly steer the state of Bob, in the sense of demonstrating genuine high-dimensional steering. In other words, Alice can convince Bob that they share an entangled state of arbitrarily high Schmidt number, while Bob can never convince Alice that the state is even simply entangled.

Partial Self-Testing and Randomness Certification in the Triangle Network.

Quantum nonlocality can be demonstrated without inputs (i.e., each party using a fixed measurement setting) in a network with independent sources.

A Case Report on Subcutaneous Emphysema and Pneumomediastinum Following a Routine Dental Procedure.

Subcutaneous emphysema (SE) and pneumomediastinum are rare complications of air beneath the skin layers and in the mediastinal space, respectively, following routine dental procedures. A few cases exist in the literature. A 53-year-old female presented to the emergency department shortly after a cavity filling, with marked swelling of her right orbit, face, and neck.

Association Between the Pulmonary Artery Pulsatility Index and Prognosis in Pulmonary Arterial Hypertension: A Multicentre Study.

Background: Risk stratification is fundamental in the management of pulmonary arterial hypertension (PAH). Pulmonary artery pulsatility index (PAPi), defined as pulmonary arterial pulse pressure divided by right atrial pressure (RAP), is a hemodynamic index shown to predict acute right ventricular (RV) dysfunction in several settings. Our objective was to test the prognostic utility of PAPi in a diverse multicentre cohort of patients with PAH.

Starting at the community: Treatment-seeking pathways of children with suspected severe malaria in Uganda.

Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always follow this recommendation. This study aimed at identifying post-referral treatment-seeking pathways that lead to appropriate antimalarial treatment for children less than five years with suspected severe malaria.

Correction: Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: An operational study.

[This corrects the article DOI: 10.1371/journal.pmed.

The invariant chain CD74 protein is a cell surface binding partner of TIMP-1 in breast cancer cells.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the homeostasis of the extracellular matrix. Beyond its well-known role in tissue maintenance, TIMP-1 has been associated with multiple MMP-independent cytokine-like functions. The protein structure of TIMP-1, with two distinct domains, one interacting with MMPs and another able to bind multiple partners, provides a rationale for this multifunctionality.

Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia.

Background & Aims: Colonic adenomatous polyps, or adenomas, are frequent precancerous lesions and the origin of most cases of colorectal adenocarcinoma. However, we know from epidemiologic studies that although most colorectal cancers (CRCs) originate from adenomas, only a small fraction of adenomas (3%-5%) ever progress to cancer. At present, there are no molecular markers to guide follow-up surveillance programs.

Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: An operational study.

Background: For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antimalarial and oral artemisinin-based combination therapy (ACT). This study aimed to assess compliance with this treatment recommendation in children under 5 years.

Methods And Findings: This observational study accompanied the implementation of RAS in the Democratic Republic of the Congo (DRC), Nigeria, and Uganda between 2018 and 2020.

Operational Definition of the Temperature of a Quantum State.

Temperature is usually defined for physical systems at thermal equilibrium. Nevertheless one may wonder if it would be possible to attribute a meaningful notion of temperature to an arbitrary quantum state, beyond simply the thermal (Gibbs) state. In this Letter, we propose such a notion of temperature considering an operational task, inspired by the zeroth law of thermodynamics.

Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints.

Background: Rectal artesunate, an efficacious pre-referral treatment for severe malaria in children, was deployed at scale in Uganda, Nigeria, and DR Congo. In addition to distributing rectal artesunate, implementation required additional investments in crucial but neglected components in the care for severe malaria. We examined the real-world costs and constraints to rectal artesunate implementation.

Simulability of High-Dimensional Quantum Measurements.

We investigate the compression of quantum information with respect to a given set M of high-dimensional measurements. This leads to a notion of simulability, where we demand that the statistics obtained from M and an arbitrary quantum state ρ are recovered exactly by first compressing ρ into a lower-dimensional space, followed by some quantum measurements. A full quantum compression is possible, i.

Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda.

Background: For children below 6 years with suspected severe malaria attending a health care provider unable to provide parenteral malaria treatment, pre-referral rectal artesunate (RAS) is recommended by the World Health Organization to prevent death and disability. A number of African countries are in the process of rolling out quality-assured RAS for pre-referral treatment of severe malaria at community-level. The success of RAS depends, among other factors, on the acceptability of RAS in the communities where it is being rolled-out.

Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study.

Background: To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials may be difficult. A randomised controlled trial found pre-referral treatment with rectal artesunate (RAS) to reduce deaths and disability in children who arrived at a referral facility with delay.

Parameter estimation of the Solow-Swan fundamental differential equation.

Background: The Solow-Swan model describes the long-term growth of the capital to labor ratio by the fundamental differential equation of Solow-Swan theory. In conventional approaches, this equation was fitted to data using additional information, such as the rates of population growth, capital depreciation, or saving. However, this was not the best possible fit.

Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo.

Background: Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings in Africa. Recognition of danger signs indicative of severe malaria is critical for prompt and appropriate case management.

Methods: This was an observational study conducted in three Health Zones of the Democratic Republic of the Congo to determine the distribution of dangers signs for severe malaria and assess their impact on RAS use, referral completion, injectable treatment and ACT provision, and health outcomes including death.

Semi-Device-Independent Certification of Causal Nonseparability with Trusted Quantum Inputs.

While the standard formulation of quantum theory assumes a fixed background causal structure, one can relax this assumption within the so-called process matrix framework. Remarkably, some processes, termed causally nonseparable, are incompatible with a definite causal order. We explore a form of certification of causal nonseparability in a semi-device-independent scenario where the involved parties receive trusted quantum inputs, but whose operations are otherwise uncharacterized.