Publications by authors named "Brunet Catherine"
Per- and polyfluoroalkyl substances (PFAS) form a vast family comprising more than 4700 synthetic compounds. Their molecules contain a terminal functional group and a hydrophobic carbon tail (alkyl group) at which the hydrogen atoms are totally (in the case of perfluorinated compounds) or partially (in the case of polyfluorinated compounds) replaced by fluorine atoms. Due to the very specific properties of their structure, they have been used in a vast range of applications over the last 70 years.
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- Enoxaparin dosage for obese patients and those with renal impairment is debated, and a study was conducted to compare anti-factor Xa activity in these groups against patients with normal weight and kidney function.
- A total of 233 patients participated, receiving either a 1.5 mg/kg once daily or a 1 mg/kg twice daily regimen of enoxaparin, with anti-Xa levels measured shortly after administration.
- The results indicated that while anti-Xa levels increased with body mass index, no dosage changes are needed for obese patients; however, patients with severe renal impairment might need dosage adjustments when taking the medication twice daily.