Publications by authors named "Brunella Corrado"

Article Synopsis
  • Natural polymers are being used more because they are less harmful, and bacterial cellulose is a really good example because it works well for medical uses.
  • This study focused on understanding the tiny structure of bacterial cellulose from a special mix of bacteria and yeast called SCOBY, using advanced microscopes.
  • We found that the structure changes as it rises in a liquid, and we can measure these changes without needing complex prep work, showing that SCOBY can create unique cellulose materials for different uses.
View Article and Find Full Text PDF

Ion channels in the blood-brain barrier (BBB) play a main role in controlling the interstitial fluid composition and cerebral blood flow, and their dysfunction contributes to the disruption of the BBB occurring in many neurological diseases such as epilepsy. In this study, using morphological and functional approaches, we evaluated the expression and role in the BBB of Kv7 channels, a family of voltage-gated potassium channels including five members (Kv7.1-5) that play a major role in the regulation of cell excitability and transmembrane flux of potassium ions.

View Article and Find Full Text PDF

The study of novel drug delivery systems represents one of the frontiers of the biomedical research area. Multi-disciplinary scientific approaches combining traditional or engineered technologies are used to provide major advances in improving drug bioavailability, rate of release, cell/tissue specificity and therapeutic index. Biodegradable and bio-absorbable polymers are usually the building blocks of these systems, and their copolymers are employed to create delivery components.

View Article and Find Full Text PDF

Bacterial cellulose (BC) is a highly pure form of cellulose produced by bacteria, which possesses numerous advantages such as good mechanical properties, high chemical flexibility, and the ability to assemble in nanostructures. Thanks to these features, it achieved a key role in the biomedical field and in drug delivery applications. BC showed its ability to modulate the release of several drugs and biomolecules to the skin, thus improving their clinical outcomes.

View Article and Find Full Text PDF

Intestine-Liver-on-chip systems can be useful to predict oral drug administration and first-pass metabolism in order to partly replace the animal model. While organ-on-chip technology can count on sophisticated micro-physiological devices, the engineered organs still remain artificial surrogates of the native counterparts. Here, we used a bottom-up tissue engineering strategy to build-up physiologically functional 3D Human Intestine Model (3D-HIM) as well as 3D Liver-microtissues (HepG2-μTPs) and designed a microfluidic Intestine-Liver-On-Chip (InLiver-OC) to emulate first-pass mechanism occurring .

View Article and Find Full Text PDF
Article Synopsis
  • Scientists created a special device called an intestine-on-chip to study how our intestines work and react to different things in a human-like way.
  • *This device helps make the cells in our intestines grow and change more quickly and creates a better environment for studying them.
  • *It is a cheap and easy tool that lets researchers see how gut cells behave, including their ability to make mucus and protect themselves after being treated with certain nutrients.
View Article and Find Full Text PDF
Article Synopsis
  • Researchers created a mini-liver on a chip to study how liver cells work and react to different substances.
  • They compared two types of liver-like models, finding that microtissue precursors worked better than cell clusters for keeping cells alive and functioning.
  • The chip was tested with ethanol to see how well it could detoxify, and the results showed it could help in developing new drugs and understanding toxicity in humans.
View Article and Find Full Text PDF