Publications by authors named "Bruneel F"
Background: Cancer patients who are exposed to sepsis and had previous chemotherapy may have increased severity. Among chemotherapeutic agents, anthracyclines have been associated with cardiac toxicity. Like other chemotherapeutic agents, they may cause endothelial toxicity.
View Article and Find Full Text PDFBackground: Acute pulmonary embolism (PE) is a life-threatening situation in cancer patients. In this situation, anticoagulant therapy is complex to administer due to the risk of bleeding. Only few studies have been conducted when these patients are admitted to the intensive care unit (ICU).
View Article and Find Full Text PDFWe studied 50 patients with invasive nocardiosis treated during 2004-2023 in intensive care centers in France and Belgium. Most (65%) died in the intensive care unit or in the year after admission. Nocardia infections should be included in the differential diagnoses for patients in the intensive care setting.
View Article and Find Full Text PDFPsychological resilience (the ability to thrive in adversity) may protect against mental-health symptoms in healthcare professionals during coronavirus disease (COVID-19) waves. To identify determinants of resilience in ICU staff members. In this cross-sectional survey in 21 French ICUs, staff members completed the 10-item Connor-Davidson Resilience Scale, Hospital Anxiety and Depression Scale, and Impact of Event Scale-Revised (for post-traumatic stress disorder [PTSD]).
View Article and Find Full Text PDFArticle Synopsis
- Acute respiratory failure (ARF) is common in ICU admissions, particularly among immunocompromised patients, yet there is limited understanding of the role of viruses in this context.
- In a study of 4038 immunocompromised patients, 9.2% had virus-detected ARF, with influenza being the most prevalent virus; significant mortality and factors influencing it were identified, including neutropenia and invasive mechanical ventilation needs.
- Remarkably, patients with virus-detected ARF had lower mortality rates compared to those with ARF from other causes, suggesting that certain viruses may have a less severe impact overall.
Ceftobiprole (CBP) is an anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin with a wide spectrum of activity. We aimed to describe our experience of real-life use of CBP for the treatment of severe infections of critically ill patients with multiple infected sites and related trough CBP concentrations. We performed a retrospective, observational, monocentric study in our intensive care unit (ICU) that included all patients treated with CBP for documented infections between January 2016 and December 2021.
View Article and Find Full Text PDFBackground: Both AIDS-defining and non-AIDS-defining cancers (ADC/NADC) predispose people living with HIV (PLHIV) to critical illnesses. The objective of this multicentre study was to investigate the prognostic impact of ADC and NADC in PLHIV admitted to the intensive care unit (ICU).
Methods: All PLHIV admitted over the 2015-2020 period in 12 university-affiliated ICUs in France were included in the study cohort.
Article Synopsis
- Imported malaria is becoming a significant health issue in non-endemic countries, particularly due to increased global travel, prompting a study to explore cytokine profiles in affected individuals in France.
- The research involved 278 adults with Plasmodium falciparum malaria, classifying them into uncomplicated (UM) and severe malaria (SM), with findings showing a notable association between high IL-10 levels and both disease severity and higher parasitemia.
- The study revealed that many patients had undetectable cytokine levels at admission, indicating that routine cytokine testing may not be useful, but high IL-10 concentrations could be important for monitoring severe cases and potential infections.
Background: This study was carried out to compare characteristics and outcomes in patients with acute respiratory failure related to COVID-19 during first, second, and third waves.
Methods: We included consecutive adults admitted to the intensive care unit between March 2020 and July 2021. We compared three groups defined by the epidemic intake phase: waves 1 (W1), 2 (W2), and 3 (W3).
Introduction: Conflicts between relatives and physicians may arise when decisions are being made about limiting life-sustaining therapies (LST). The aim of this study was to describe the motives for, and management of team-family conflicts surrounding LST limitation decisions in French adult ICUs.
Methods: Between June and October 2021, French ICU physicians were invited to answer a questionnaire.
Article Synopsis
- This study aimed to understand the outcomes of patients with severe meningoencephalitis in intensive care, analyzing data from 599 adults across 68 medical centers in 7 countries from 2017 to 2020.
- Results showed that more than half of the patients (50.5%) had poor functional outcomes at three months, with 25.8% resulting in death; causes of meningoencephalitis were varied, with acute bacterial meningitis being the most common.
- Key factors linked to worse outcomes included being older than 60, having a weakened immune system, delays in ICU admission, and severe neurological impairments, highlighting the need for timely care and monitoring.
Introduction: The high prevalence of deep vein thrombosis (DVT) in patients admitted to intensive care unit (ICU) for COVID-19-related acute respiratory distress syndrome (ARDS) would justify systematic screening of these patients or higher therapeutic dose of heparin for thromboprophylaxis.
Material And Method: We performed a systematic echo-Doppler of the lower limb proximal veins during the first 48 h (visit 1) and from 7 to 9 days after visit 1 (visit 2) in consecutive patients admitted to the ICU of a university-affiliated tertiary hospital for severe proven COVID-19 during the second wave. All patients received intermediate-dose heparin (IDH).
Coagulation disorders increase mortality rate during septic shock, but the impact of concomitant hematological malignancies remains unknown. The study assessed coagulation disorders in onco-hematological patients with thrombocytopenia (<100 G/L) admitted to ICU for septic shock. Among 146 included patients, 50 patients had lymphoma and 49 patients had acute leukemia.
View Article and Find Full Text PDFIntroduction: Lumbar puncture is among the investigations used to identify various neurological conditions, including some that can cause cardiac arrest (CA). However, CA per se may alter cerebrospinal fluid (CSF) characteristics. Few studies have investigated CSF findings after CA.
View Article and Find Full Text PDFPurpose: To study prevalence of targeted therapy (TT)-related adverse events requiring ICU admission in solid tumor patients.
Methods: Retrospective multicenter study from the Nine-i research group. Adult patients who received TT for solid tumor within 3 months prior to ICU admission were included.
Background: During the coronavirus disease 2019 (COVID-19) pandemic, 60-80% of patients admitted to ICU require mechanical ventilation for respiratory distress. We aimed to compare the frequency of postextubation stridor (PES) and to explore risk factors in COVID-19 subjects compared to those without COVID-19.
Methods: We performed an observational retrospective study on subjects admitted for severe COVID-19 requiring mechanical ventilation > 48 h during the first and second waves in 2020 and compared these subjects to historical controls without COVID-19 who received mechanical ventilation > 48 h between 2016-2019.
Article Synopsis
- - Study explores the impact of COVID-19-related ARDS on the mental health of family members, particularly focusing on PTSD symptoms compared to ARDS caused by other conditions.
- - Conducted in 23 ICUs in France, the research included 602 family members and examined their psychological state 90 days post-ICU, utilizing specific assessment scales for PTSD, anxiety, and depression.
- - Findings indicate that family members of patients who suffered from COVID-19 ARDS reported significantly higher levels of PTSD symptoms compared to those whose relatives had ARDS from other causes.
Article Synopsis
- - The study examined the impact of ventilator type on hospital mortality for patients with ARDS due to COVID-19 in a French ICU from March 2020 to July 2021.
- - Out of 189 patients, factors such as age over 70, immunodeficiency, and high serum creatinine levels were linked to higher mortality, while the type of ventilator used did not influence survival rates.
- - Both ICU settings (standard vs. transient ICU with simpler ventilators) showed similar lengths of mechanical ventilation and ICU stays, indicating that less complex ventilators did not lead to worse patient outcomes.
Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors and outcome of BSI in critically ill coronavirus infectious disease-19 (COVID-19) patients.
Patients And Methods: We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU study) that included 4010 COVID-19 ICU patients.
Objectives: Geotrichum spp can be responsible for severe infections in immunocompromised patients. We aim to describe Geotrichum-related infections in the ICU and to assess risk factors of mortality.
Methods: Retrospective multicentre study, conducted in 14 French ICUs between 2002 and 2018, including critically ill adult patients with proven or probable infection related to Geotrichum species.