Publications by authors named "Bruna Teles Pinheiro"
Introduction: The spread of the HTLV infection in families living in the metropolitan area of Belém, Pará, Brazil, and the lack of studies in the general population requires studies to better understand its prevalence in the region.
Methods: An anti-HTLV-1/HTLV-2 antibodies test was carried out on random adults in public places in Belém between November 2014 and November 2015. A proviral DNA test detected if the person was infected, and then a clinical evaluation and an intrafamilial investigation were carried out.
Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.
Virol J
May 2018
Article Synopsis
- HTLV-1, a virus affecting 2-5 million people globally, is linked to various diseases and has genetically stable envelope glycoproteins (gp), particularly the gp46 gene, which impacts infectivity and immune response.
- A study in Belém, Brazil, analyzed 40 HTLV-1 patients over five years, finding that most were symptomatic and carried a common genotype with low mutation rates, indicating genetic stability.
- Notably, 66.6% of symptomatic patients had amino acid mutations, with a new mutation (N93D) linked to symptomatic cases, highlighting potential implications for disease management.
The Human T-cell Lymphotropic Virus (HTLV-1) is a Deltaretrovírus that was first isolated in the 1970s, and associated with Adult T-cell Leucemia-Lymphoma (ATLL), and subsequently to Tropical Spastic Paraparesis-Myelopathy (TSP/HAM). The genetic diversity of the virus varies among geographic regions, although its mutation rate is very low (approximately 1% per thousand years) in comparison with other viruses. The present study determined the genetic diversity of HTLV-1 in the metropolitan region of Belém, in northern Brazil.
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