Psychotropic Polypharmacy Leading to Reversible Dementia: A Case Report.

Psychotropic polypharmacy presents a diagnostic challenge that may be further complicated by inadequate medication history and underappreciation of the cognitive effects of such polypharmacy. Here we present the case of a 57-year-old man who presented to our memory clinic with progressive cognitive decline and a prior neuropsychological evaluation supporting the diagnosis of a neurodegenerative disorder. He was taking multiple psychotropic medications at the time, but the exact dosages were unclear due to a lack of collateral history.

Relationships between neuropsychiatric symptoms and cognitive profiles in Alzheimer's disease and related syndromes.

Objectives: To investigate the rate of occurrence of neuropsychiatric symptoms (NPS) and their relationship with age, sex and cognitive performance in subjects with Alzheimer's disease and related dementias (Alzheimer's disease and related dementias [ADRD]).

Methods: This is a retrospective matched case-control study. Data from memory clinic patients included demographic information presence of NPS, and cognitive testing of Orientation, Immediate and Delayed Memory, Visuospatial Function, Working Memory, Attention, Executive Control and Language.

Episodic memory decline is associated with deficits in coherence of discourse.

This study investigates coherence of discourse in the production of autobiographical narratives by individuals with aMCI. Autobiographical interviews were analyzed to determine whether reduced episodic recall was related to deficits in discourse coherence. A coherence rating scale was used to evaluate relatedness of the autobiographical details produced by participants to the topic of discourse.

Impaired coherence for semantic but not episodic autobiographical memory in semantic variant primary progressive aphasia.

Language deficits, including word-finding difficulties and impaired single-word comprehension, have been found in patients with semantic variant primary progressive aphasia (svPPA). These deficits characterize the linguistic abilities of patients with svPPA on a micro-linguistic level (word and sentence level). On a macro-linguistic level (discourse level), svPPA patients' discourse has been described as "empty".