Osteogenic potential of a chalcone in a critical-size defect in rat calvaria bone.

Background: This study describes the bone formation stimulated by the application of a type of chalcone to critical-size defects in rat calvarial bone.

Material And Methods: Sixty female Wistar rats were divided into 6 groups of 10 animals per group: control (no treatment), vehicle (vaseline) and the chalcone (1-phenyl-3-(4-chlorophenyl)-2-propen-1-one) suspended in vaseline at 10%. A critical-size defect of 5 mm was prepared using a trephine in the calvarial bone, after which the treatment was applied, in a single dose, according to the experimental group.

Antinociceptive activity and preliminary structure-activity relationship of chalcone-like compounds.

Chalcones belong to a class of alpha,beta,-unsaturated aromatic ketones which occur abundantly in nature, especially in plants. They are promising and interesting compounds due to their vast applications in pharmaceuticals, agriculture and industry. Several studies have shown that these compounds exert important biological activities in different experimental models.