Publications by authors named "Bruna Melhoranse-Gouveia"

Lentigo maligna (LM) is a growing problem worldwide and the main type of melanoma in situ in some Caucasian populations. It presents as a spectrum from atypical intraepidermal melanocytic proliferation (AIMP) to invasive lentigo maligna melanoma (LMM). Accurate diagnosis and staging are crucial for determining appropriate management strategies.

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Article Synopsis
  • Cutaneous confocal microscopy (CCCM) is a technique that allows for detailed imaging of the skin at a cellular level, and this study tested a remote version (Remote-CCM) to enhance access to skin cancer diagnoses.
  • In the study, 201 lesions were assessed, with Remote-CCM showing a sensitivity of 89% for detecting skin malignancies and a specificity of 64%, effectively reducing unnecessary biopsies in 90% of benign cases.
  • The findings suggest that while Remote-CCM is accurate and can lower biopsy rates, it may not be suitable for potential cases of squamous cell carcinoma (SCC), indicating a need for follow-up on uncertain melanoc
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Lentigo maligna (LM) is an early form of pre-invasive melanoma that predominantly affects sun-exposed areas such as the face. LM is highly treatable when identified early but has an ill-defined clinical border and a high rate of recurrence. Atypical intraepidermal melanocytic proliferation (AIMP), also known as atypical melanocytic hyperplasia (AMH), is a histological description that indicates melanocytic proliferation with uncertain malignant potential.

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Background: Lentigo maligna (LM), a form of melanoma in situ, has no risk of causing metastasis unless dermal invasive melanoma (LMM) supervenes. Furthermore, the detection of invasion impacts prognosis and management.

Objective: To assess the accuracy of RCM for the detection of invasion component on LM/LMM lesions.

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Optical Coherence Tomography (OCT) is a useful non-invasive diagnostic tool for diagnosing and monitoring treatment of basal cell carcinomas. We describe the use of OCT in a patient with Basal Cell Naevus Syndrome. Through measuring tumour depth on OCT, management of individual tumours was triaged accordingly using 0.

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Lentigo maligna (LM) can be difficult to diagnose and recurrence is not uncommon. In vivo reflectance confocal microscopy (RCM) improves diagnostic accuracy of LM. LM can be difficult to discern from coexistent metal-induced cutaneous hyperpigmentation (MICH).

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A 3.5-month-old boy presented with a changing medium-sized congenital melanocytic nevus on his leg. Due to atypical features on dermoscopy and reflectance confocal microscopy (RCM), an excision of the area of concern was performed.

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Background: Reflectance confocal microscopy (RCM) is a useful tool for many skin cancers, allowing non-invasive evaluation over time and identifying areas of active disease. Its role to follow-up mycosis fungoides (MF) patients has not yet been evaluated.

Objective: To assess the level of agreement between RCM and histopathology and to develop a RCM checklist that could help monitoring MF patients.

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Patients with mycosis fungoides typically experience an indolent disease. In some cases, the disease undergoes a process of large cell transformation which often heralds a more aggressive course with shortened overall survival. In order to rule out large cell transformation, biopsy specimens are often collected from patients with established disease who develop new papules, plaques or tumours.

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Article Synopsis
  • Reflectance confocal microscopy (RCM) is a non-invasive imaging technique used to aid in the diagnosis of cutaneous T-cell lymphomas (CTCL), which can often be challenging due to ambiguous symptoms.
  • This study systematically reviewed and identified RCM features associated with CTCL, noting eighteen distinct characteristics with the most common being interface dermatitis and epidermal lymphocytes.
  • The researchers proposed a grading system for these RCM features to help standardize assessment and improve the diagnostic and monitoring processes for CTCL patients.
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The authors present a case of onychomatricoma, a rare benign tumour of the nail matrix, first described by Baran and Kint in 1992. The lesion appeared on the proximal nail fold, covering half the nail of the second left finger. The nail was thickened and yellowish with longitudinal melanonychia.

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Squamous cell carcinoma (SCC) is the second-most common malignant cutaneous cancer, with 60% occurring in the head and neck region. Metastases are uncommon and imply a more conservative prognosis. This report describes a case of parotid-invasive, facial squamous cell carcinoma, highlighting the importance of its prognostic and therapeutic management.

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