Schwann cell TRPA1 elicits reserpine-induced fibromyalgia pain in mice.

Background And Purpose: Fibromyalgia is a complex clinical disorder with an unknown aetiology, characterized by generalized pain and co-morbid symptoms such as anxiety and depression. An imbalance of oxidants and antioxidants is proposed to play a pivotal role in the pathogenesis of fibromyalgia symptoms. However, the precise mechanisms by which oxidative stress contributes to fibromyalgia-induced pain remain unclear.

Evaluation of the functional capacity and quality of life of children and adolescents during and after cancer treatment.

Objective: To evaluate the functional capacity and quality of life of children and adolescents during cancer treatment and post-treatment.

Methods: Cross-sectional study of patients during cancer treatment and post-treatment, assessed by the 6-minute walk test (6MWT) and the Pediatric Quality of Life ™ questionnaire (cancer module).

Results: Sixty-five patients, aged 11.

Antimicrobial and Toxicity Evaluation of Imidazolium-Based Dicationic Ionic Liquids with Dicarboxylate Anions.

Imidazolium-based dicationic ILs (DILs) presenting antimicrobial activity and relatively low toxicity are highly desirable and are envisioned for use in live tissue to prevent bacterial or fungal infections. In this context, we present here DILs with dicarboxylate anions [C(MIM)[C(MIM)][CO-(CH)CO], in which = 4, 6, 8, and 10, and m = 0, 1, 2, 3, 4, and 5. The results showed that DILs with an alkyl chain spacer of ten carbons were active against yeasts and the bacterial strains tested.

Synergic effects of ultrasound and ionic liquids on fluconazole emulsion.

The aim of this work was to evaluate the influence of US on the properties of the fluconazole emulsions prepared using imidazolium-based ILs ([C Cim]Br). The effects of the preparation method (mechanical stirring or US), US amplitude, alkyl chain length (of [CCim]Br or [CCim]Br), and IL concentration on the physicochemical properties were evaluated. Properties such as droplet size, span index, morphology, viscosity encapsulation efficiency, and drug release profile were determined.