Publications by authors named "Bruna Kochhann Menezes"
Braz J Microbiol
March 2020
Article Synopsis
- - The study aimed to analyze how effective daptomycin is against vancomycin-resistant Enterococcus faecium bacteraemia, using computer modeling techniques, particularly PK/PD modeling and Monte Carlo simulations.
- - Researchers evaluated the drug's effectiveness through time-kill curves and found significant reductions in bacterial counts with daptomycin doses between 6-10 mg/kg over 18 days, especially in individuals with better kidney function (creatinine clearance of 15-100 mL/min).
- - The findings indicate that while higher doses of daptomycin lead to better therapeutic responses, administering it every 48 hours is not enough to effectively treat the infection, suggesting a need for more frequent dosing.
