Annexin A1-derived peptide Ac in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects.

Background: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac in an experimental model of status epilepticus (SE) was evaluated.