Publications by authors named "Bruna Cogo Borin"
Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications.
Fernanda D'Avila da Silva Maria Eduarda de Andrade Galiciolli Ana Carolina Irioda Cláudia Sirlene Oliveira Bruna Candia Piccoli Bruna Cogo Borin
Blood Cells Mol Dis
May 2024
Article Synopsis
- - The study investigates the cytotoxic effects of JM-20, a compound potentially harmful to blood cells, by assessing cell viability, morphology changes, and oxidative stress in human leukocytes and erythrocytes.
- - Results showed that while low concentrations (10 μM) of JM-20 had a cytoprotective effect, higher concentrations (20 and 50 μM) significantly decreased leukocyte viability and increased reactive species levels, indicating potential toxicity.
- - JM-20 demonstrated strong antioxidant properties comparable to α-tocopherol, effectively reducing lipid peroxidation and DPPH radical levels, without causing significant hemolysis, cell cycle changes, or DNA damage.
Development of a nanotechnological-based hydrogel containing a novel benzofuroazepine compound in association with vitamin E: An in vitro biological safety and photoprotective hydrogel.
Vinicius Costa Prado Marcel Henrique Marcondes Sari Bruna Cogo Borin Roberto do Carmo Pinheiro Letícia Cruz
Colloids Surf B Biointerfaces
March 2021
This study aimed to evaluate the potential DNA photoprotection of nano-based hydrogels containing a novel benzofuroazepine molecule. Photoprotective property of three benzofuroazepine derivative compounds was assessed by determining a UV light absorptive profile. Nanocapsule suspensions (Eudragit® RS 100 as polymeric wall and medium-chain triglyceride or vitamin E as oil core) containing the benzofuroazepine compound that had the best UV spectral absorption were developed and physicochemically characterized.
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