Coumarin/β-Cyclodextrin Inclusion Complexes Promote Acceleration and Improvement of Wound Healing.

Coumarins have great pharmacotherapeutic potential, presenting several biological and pharmaceutical applications, like antibiotic, fungicidal, anti-inflammatory, anticancer, anti-HIV, and healing activities, among others. These molecules are practically insoluble in water, and for biological applications, it became necessary to complex them with cyclodextrins (CDs), which influence their bioavailability in the target organism. In this work, we studied two coumarins, and it was possible to conclude that there were structural differences between 4,7-dimethyl-2-chromen-2-one (DMC) and 7-methoxy-4-methyl-2-chromen-2-one (MMC)/β-CD that were solubilized in ethanol, frozen, and lyophilized (FL) and the mechanical mixtures (MM).

Magnetic solid-phase extraction based on restricted-access molecularly imprinted polymers for ultrarapid determination of ractopamine residues from food samples by capillary electrophoresis.

An ultrafast, efficient, and eco-friendly method combining magnetic solid phase extraction and capillary electrophoresis with diode array detection have been developed to determine ractopamine residues in food samples. A restricted access material based on magnetic and mesoporous molecularly imprinted polymer has been properly synthesized and characterized, demonstrating excellent selectivity and high adsorbent capacity. Short-end injection capillary electrophoresis method was optimized: 75 mM triethylamine pH 7 as BGE, -20 kV, 50 mbar by hydrodynamic injection during 8 s, and capillary temperature at 25 °C; reaching ultrafast ractopamine analysis (∼0.

Restricted double access mesoporous polypyrrole as adsorbent in pipette-tip solid phase extraction for simultaneous determination of progesterone, pyriproxyfen, and deltamethrin in chicken eggs.

In this study, two sample preparation techniques were evaluated in the simultaneous determination of three compounds with different physicochemical properties, progesterone, pyriproxyfen, and deltamethrin that may be present in the chicken egg. In this procedure, firstly the restricted double access mesoporous polypyrrole was synthesized, which was evaluated as adsorbent in pipette-tip solid phase extraction and dispersive solid phase extraction. After optimizing the extraction parameters, it was found that pipette-tip solid phase extraction was more efficient and, therefore, it was used in the validation and application of the method.

Synthesis of mesoporous magnetic polypyrrole and its application in studies of removal of acidic, neutral, and basic pharmaceuticals from aqueous medium.

As an alternative to traditional adsorbents, mesoporous magnetic polypyrrole (MMPPy) was first used as an adsorbent for the removal of acid, neutral, and basic pharmaceutical compounds considered aqueous pollutants. Ibuprofen (IBU, acid), caffeine (CAF, neutral), and bupropion (BUP, basic) were chosen as adsorbates and applied in adsorption studies. They proved to be pH dependent of the aqueous solution and the best results were found at pH 4 for IBU and CAF and pH 7 for BUP and 60 mg was the optimal amount of adsorbent to be used in the studies.

Functional polyaniline/multiwalled carbon nanotube composite as an efficient adsorbent material for removing pharmaceuticals from aqueous media.

The composite polyaniline/multiwalled carbon nanotube (PAni/MWCNT, 1:0.1 w/w) was developed with the intention of binding the adsorbent properties of two materials and using it to adsorb pharmaceuticals from aqueous media. PAni/MWCNT was characterized by scanning electron microscopy, thermogravimetry, infrared spectroscopy, pH at the point of zero charge, and the effect on the surface wettability of the material.

Pipette-tip solid-phase extraction using polypyrrole as efficient adsorbent for extraction of avermectins and milbemycins in milk.

In this work, we developed a HPLC method for the multidetermination of avermectins (AVM) (abamectin-ABA 1b and ABA 1a, eprinomectin-EPR, and ivermectin-IVM) and milbemycins (moxidectin-MOX) in milk samples using polypyrrole (PPy) as adsorbent material in pipette-tip solid-phase extraction (PT-PPy-SPE). PPy was characterized by scanning electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, and X-ray diffraction and the data agreed with the literature. The sample preparation included the clean-up of the milk by protein precipitation (PP) with acetonitrile and extraction of the analytes by PT-PPy-SPE.