Publications by authors named "Bruna C Casarin"
The COVID-19 pandemic has been marked by novel viral variants, posing challenges to global public health. Recombination, a viral evolution mechanism, is implicated in SARS-CoV-2's ongoing evolution. The XBB recombinant lineage, known for evading antibody-mediated immunity, exhibits higher transmissibility without increased disease severity.
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- The study investigates the spread of the Delta variant of SARS-CoV-2 in the RS state of Brazil from June to October 2021, identifying 65.3% of samples as Delta and 34.7% as Gamma.
- It highlights the rapid introduction of the Delta variant, which accounted for over 70% of cases within nine weeks, while 99.2% of Delta sequences belonged to a specific Brazilian lineage.
- The research emphasizes the role of genomic surveillance in tracking viral evolution and notes that the continued stability in case numbers and deaths may be attributed to factors like vaccinations and mask mandates.
Antimicrobial-resistant Klebsiella pneumoniae is a global threat to healthcare and an important cause of nosocomial infections. Antimicrobial resistance causes prolonged treatment periods, high mortality rates, and economic impacts. Whole Genome Sequencing (WGS) has been used in laboratory diagnosis, but there is limited evidence about pipeline validation to parse generated data.
View Article and Find Full Text PDFWith the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated.
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