Publications by authors named "Bruna Aparecida Fonseca da Silva"
Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension.
J Appl Physiol (1985)
January 2025
Article Synopsis
- The study investigated whether combined moderate-intensity exercise could slow down harmful changes in the lungs and right heart in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).
- Rats underwent a 3-week exercise program including aerobic and resistance training, which improved their physical endurance and prevented negative changes in pulmonary artery resistance and right ventricular function.
- The exercise also helped maintain heart cell function, reduced structural damage to the right ventricle and lungs, and lowered oxidative stress levels associated with PAH.
Combined physical training protects the left ventricle from structural and functional damages in experimental pulmonary arterial hypertension.
Clin Hypertens
May 2024
Background: Under the adverse remodeling of the right ventricle and interventricular septum in pulmonary arterial hypertension (PAH) the left ventricle (LV) dynamics is impaired. Despite the benefits of combined aerobic and resistance physical trainings to individuals with PAH, its impact on the LV is not fully understood.
Objective: To test whether moderate-intensity combined physical training performed during the development of PAH induced by MCT in rats is beneficial to the LV's structure and function.
Resistance exercise training benefits pulmonary, cardiac, and muscular structure and function in rats with stable pulmonary artery hypertension.
Life Sci
November 2023
Aim: We tested the effects of low- to moderate-intensity resistance exercise training (RT) on the structure and function of pulmonary, right ventricle (RV), and skeletal muscle tissues in rats with stable pulmonary artery hypertension (PAH).
Main Methods: After the first monocrotaline (MCT; 20 mg/kg) injection, male rats were submitted to a RT program (Ladder climbing; 55-65 % intensity), 5 times/week. Seven days later rats received the second MCT dose.
Background: The right ventricular hypertrophy and dilation observed in pulmonary artery hypertension (PAH) damages the left ventricle (LV) dynamics by flattening the interventricular septum.
Objective: To investigate whether low- to moderate-intensity resistance exercise training (RT) is beneficial to LV and cardiomyocyte contractile functions in rats during the development of monocrotaline (MCT)-induced PAH.
Methods: Male Wistar rats (Body weight: ~ 200 g) were used.