Publications by authors named "Bruna Andreotti da Silva Amaral"
Dipyrone is a commonly used analgesic in many countries and there is limited data on its possible endocrine disrupting effects. We performed a screening for in vivo and in vitro anti(estrogenic) activity of dipyrone. For the in vivo uterotrophic assay, immature female rats (22-days-old) were treated daily by oral gavage for three days with different doses of dipyrone alone (50, 100, 200 mg/kg/day) and associated with three ethynylestradiol (EE) doses (1, 3 and 10 μg/kg/day), which were based on a dose-response curve experiment.
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- - The study investigated the effects of dipyrone and its metabolites (MAA and AA) on steroid hormone production, indicating that these substances may inhibit steroid hormone production in human cells but only at high concentrations not typically seen in medical usage.
- - In tests, dipyrone and its metabolites reduced androgen (testosterone) and corticosteroid production in lab cells but did not impact fetal testosterone production in rats exposed during pregnancy.
- - Additionally, dipyrone and its metabolites showed no androgenic activity in specialized assays, suggesting they do not interact with androgen receptors despite the potential to lower steroid hormone production under certain conditions.