Publications by authors named "Bruce Segal"
Article Synopsis
- - The study aimed to evaluate the long-term safety and effectiveness of perfluorohexyloctane (PFHO) eye drops for treating dry eye disease (DED) through the KALAHARI trial, which followed a previous study called GOBI.
- - In the KALAHARI trial, 208 patients used PFHO drops for a year, with safety assessments indicating mostly mild adverse effects, while effectiveness was measured by improvements in corneal staining and dry eye scores.
- - Results showed that PFHO was safe and well-tolerated, effectively maintaining improvements in DED symptoms over the study period, including for patients who switched from saline to PFHO.
Purpose: Evaluate the initial ocular safety and tolerability and efficacy of VVN001 Ophthalmic Solution (VVN001), a small-molecule antagonist of lymphocyte function-associated antigen-1 (LFA-1), in subjects with dry eye disease (DED).
Methods: This was a multi-center, double-masked, randomized, dose-response, vehicle-controlled, parallel-group study conducted in 170 subjects with DED. Subjects were randomized to receive VVN001 (1% or 5%) or its vehicle, twice-daily in both eyes for 84 days.
Purpose: To evaluate the efficacy and safety of a topical ophthalmic suspension combination of povidone-iodine 0.6% (PVP-I) and dexamethasone 0.1% (DEX) for infectious and inflammatory components of bacterial conjunctivitis.
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