Complexity synchronization in living matter: a mini review.

Fractal time series have been argued to be ubiquitous in human physiology and some of the implications of that ubiquity are quite remarkable. One consequence of the omnipresent fractality is complexity synchronization (CS) observed in the interactions among simultaneously recorded physiologic time series discussed herein. This new kind of synchronization has been revealed in the interaction triad of organ-networks (ONs) consisting of the mutually interacting time series generated by the brain (electroencephalograms, EEGs), heart (electrocardiograms, ECGs), and lungs (Respiration).

Complexity Synchronization of Organ Networks.

The transdisciplinary nature of science as a whole became evident as the necessity for the complex nature of phenomena to explain social and life science, along with the physical sciences, blossomed into complexity theory and most recently into complexitysynchronization. This science motif is based on the scaling arising from the 1/f-variability in complex dynamic networks and the need for a network of networks to exchange information internally during intra-network dynamics and externally during inter-network dynamics. The measure of complexity adopted herein is the multifractal dimension of the crucial event time series generated by an organ network, and the difference in the multifractal dimensions of two organ networks quantifies the relative complexity between interacting complex networks.

Complexity synchronization: a measure of interaction between the brain, heart and lungs.

Herein we address the measurable consequences of the network effect (NE) on time series generated by different parts of the brain, heart, and lung organ-networks (ONs), which are directly related to their inter-network and intra-network interactions. Moreover, these same physiologic ONs have been shown to generate crucial event (CE) time series, and herein are shown, using modified diffusion entropy analysis (MDEA) to have scaling indices with quasiperiodic changes in complexity, as measured by scaling indices, over time. Such time series are generated by different parts of the brain, heart, and lung ONs, and the results do not depend on the underlying coherence properties of the associated time series but demonstrate a generalized synchronization of complexity.

EEG phase synchronization during absence seizures.

Absence seizures-generalized rhythmic spike-and-wave discharges (SWDs) are the defining property of childhood (CAE) and juvenile (JAE) absence epilepsies. Such seizures are the most compelling examples of pathological neuronal hypersynchrony. All the absence detection algorithms proposed so far have been derived from the properties of SWDs.

Temporal complexity measure of reaction time series: Operational versus event time.

Introduction: Detrended fluctuation analysis (DFA) is a well-established method to evaluate scaling indices of time series, which categorize the dynamics of complex systems. In the literature, DFA has been used to study the fluctuations of reaction time Y(n) time series, where n is the trial number.

Methods: Herein we propose treating each reaction time as a duration time that changes the representation from operational (trial number) time n to event (temporal) time t, or X(t).

The Fractal Tapestry of Life: II Entailment of Fractional Oncology by Physiology Networks.

This is an essay advocating the efficacy of using the (noninteger) fractional calculus (FC) for the modeling of complex dynamical systems, specifically those pertaining to biomedical phenomena in general and oncological phenomena in particular. Herein we describe how the integer calculus (IC) is often incapable of describing what were historically thought to be simple linear phenomena such as Newton's law of cooling and Brownian motion. We demonstrate that even linear dynamical systems may be more accurately described by fractional rate equations (FREs) when the experimental datasets are inconsistent with models based on the IC.

Hypothetical Control of Fatal Quarrel Variability.

Wars, terrorist attacks, as well as natural catastrophes typically result in a large number of casualties, whose distributions have been shown to belong to the class of Pareto's inverse power laws (IPLs). The number of deaths resulting from terrorist attacks are herein fit by a double Pareto probability density function (PDF). We use the fractional probability calculus to frame our arguments and to parameterize a hypothetical control process to temper a Lévy process through a collective-induced potential.

Fractional Calculus and the Future of Science.

The invitation to contribute to this anthology of articles on the fractional calculus (FC) encouraged submissions in which the authors look behind the mathematics and examine what must be true about the phenomenon to justify the replacement of an integer-order derivative with a non-integer-order (fractional) derivative (FD) before discussing ways to solve the new equations [...

Persistence and anti-persistence in treadmill walking.

Background: Strong, long-range persistent correlations in stride time (ST) and length (SL) are the fundamental traits of treadmill gait. Our recent work showed that the ST and SL time series' statistical properties originated from the superposition of large-scale trends and small-scale fluctuations (residuals). Trends served as the control manifolds about which ST and SL fluctuated.

Absence Seizure Detection Algorithm for Portable EEG Devices.

Absence seizures are generalized nonmotor epileptic seizures with abrupt onset and termination. Transient impairment of consciousness and spike-slow wave discharges (SWDs) in EEG are their characteristic manifestations. This type of seizure is severe in two common pediatric syndromes: childhood (CAE) and juvenile (JAE) absence epilepsy.

The Fractal Tapestry of Life: A Review of Fractal Physiology.

Since its inception the science of physiology, like many other non-physical disciplines, has been guided in its development by the mechanical models of physics. That strategy has proven to be extraordinarily successful, even surviving the introduction of fractals into the modeling strategy. That is until quite recently.

Why Do Big Data and Machine Learning Entail the Fractional Dynamics?

Fractional-order calculus is about the differentiation and integration of non-integer orders. Fractional calculus (FC) is based on fractional-order thinking (FOT) and has been shown to help us to understand complex systems better, improve the processing of complex signals, enhance the control of complex systems, increase the performance of optimization, and even extend the enabling of the potential for creativity. In this article, the authors discuss the fractional dynamics, FOT and rich fractional stochastic models.

Caputo Fractional Derivative and Quantum-Like Coherence.

We study two forms of anomalous diffusion, one equivalent to replacing the ordinary time derivative of the standard diffusion equation with the Caputo fractional derivative, and the other equivalent to replacing the time independent diffusion coefficient of the standard diffusion equation with a monotonic time dependence. We discuss the joint use of these prescriptions, with a phenomenological method and a theoretical projection method, leading to two apparently different diffusion equations. We prove that the two diffusion equations are equivalent and design a time series that corresponds to the anomalous diffusion equation proposed.

Diffusion Entropy vs. Multiscale and Rényi Entropy to Detect Progression of Autonomic Neuropathy.

We review the literature to argue the importance of the occurrence of crucial events in the dynamics of physiological processes. Crucial events are interpreted as short time intervals of turbulence, and the time distance between two consecutive crucial events is a waiting time distribution density with an inverse power law (IPL) index μ, with μ < 3 generating non-stationary behavior. The non-stationary condition is characterized by two regimes of the IPL index: (a) perennial non-stationarity, with 1 < μ < 2 and (b) slow evolution toward the stationary regime, with 2 < μ < 3.

Sir Isaac Newton Stranger in a Strange Land.

The theme of this essay is that the time of dominance of Newton's world view in science is drawing to a close. The harbinger of its demise was the work of Poincaré on the three-body problem and its culmination into what is now called chaos theory. The signature of chaos is the sensitive dependence on initial conditions resulting in the unpredictability of single particle trajectories.

Significance of trends in gait dynamics.

Trends in time series generated by physiological control systems are ubiquitous. Determining whether trends arise from intrinsic system dynamics or originate outside of the system is a fundamental problem of fractal series analysis. In the latter case, it is necessary to filter out the trends before attempting to quantify correlations in the noise (residuals).

Complex Periodicity and Synchronization.

A recent experiment proves the therapeutic effect of arm-in-arm walking, showing that if an aged participant walks in close synchrony with a young companion, the complexity matching effect results in the restoration of complexity in the former. A clear manifestation of complexity restoration is a perfect synchronization. The authors of this interesting experiment leave open two important problems.

Changes in Interictal Pretreatment and Posttreatment EEG in Childhood Absence Epilepsy.

Spike and wave discharges (SWDs) are a characteristic manifestation of childhood absence epilepsy (CAE). It has long been believed that they unpredictably emerge from otherwise almost normal interictal EEG. Herein, we demonstrate that pretreatment closed-eyes theta and beta EEG wavelet powers of CAE patients (20 girls and 10 boys, mean age 7.

Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine.

The gathered together 200 global thought leaders, scientists, clinicians, academicians, industry and government experts, medical and graduate students, postdoctoral scholars and policymakers. Held at Georgetown University Conference Center in Washington D.C.

Persistent random motion with maximally correlated fluctuations.

How often should a random walker change its direction of motion in order to maximize correlation in velocity fluctuations over a finite time interval? We address this optimal diffusion problem in the context of the one-dimensional persistent random walk, where we evaluate the correlation and mutual information in velocity trajectories as a function of the persistence level and the observation time. We find the optimal persistence level corresponds to the average number of direction reversals asymptotically scaling as the square root of the observation time. This square-root scaling law makes the relative growth between the average number of direction reversals and the persistence length invariant with respect to changes in the overall time duration of the random walk.

Hypothetical Control of Heart Rate Variability.

In the last three decades, the analysis of heart rate variability by nonlinear methods demonstrated the complexity of cardiovascular regulation. Additionally to the observations of periodic heart rate regulation by the autonomic nervous system, the long-term statistics of the heart rate has been determined to reminisce a tempered Lévy process. A number of heuristic arguments have previously been made to support a tempering conjecture, using exponentially truncated waiting times for the time intervals between heart beats.

Entropic Approach to the Detection of Crucial Events.

In this paper, we establish a clear distinction between two processes yielding anomalous diffusion and 1 / f noise. The first process is called Stationary Fractional Brownian Motion (SFBM) and is characterized by the use of stationary correlation functions. The second process rests on the action of crucial events generating ergodicity breakdown and aging effects.

Bridging Waves and Crucial Events in the Dynamics of the Brain.

Earlier research work on the dynamics of the brain, disclosing the existence of crucial events, is revisited for the purpose of making the action of crucial events, responsible for the 1/ -noise in the brain, compatible with the wave-like nature of the brain processes. We review the relevant neurophysiological literature to make clear that crucial events are generated by criticality. We also show that although criticality generates a strong deviation from the regular wave-like behavior, under the form of Rapid Transition Processes, the brain dynamics also host crucial events in regions of nearly coherent oscillations, thereby making many crucial events virtually invisible.

Meditation-Induced Coherence and Crucial Events.

In this paper we emphasize that 1/ noise has two different origins, one compatible with Laplace determinism and one determined by unpredictable crucial events. The dynamics of heartbeats, manifest as heart rate variability (HRV) time series, are determined by the joint action of these different memory sources with meditation turning the Laplace memory into a strongly coherent process while exerting an action on the crucial events favoring the transition from the condition of ideal 1/ noise to the Gaussian basin of attraction. This theoretical development affords a method of statistical analysis that establishes a quantitative approach to the evaluation of the stress reduction realized by the practice of Chi meditation and Kundalini Yoga.