The precision of computer-generated surgical splints.

Purpose: The purpose of this study was to assess the precision of stereolithographic surgical splints generated by the authors' computer-aided design and manufacturing (CAD/CAM) technique by comparing them with the conventional acrylic splints.

Materials And Methods: Seven volunteers were used. A pair of surgical splints, stereolithographic and conventional acrylic splints, was fabricated for each subject.

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.

The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4.