Publications by authors named "Bruce Grahn"

Article Synopsis
  • A rare myxoid intraocular neoplasm originating from the ciliary body was discovered in a 14-year-old female cat, characterized by a bubble-shaped mass that led to secondary glaucoma and necessitated enucleation.
  • Histological and immunohistochemical analysis revealed a multinodular hypocellular neoplasm with strong cytokeratin and vimentin reactivity, suggesting an epithelioid myxosarcoma diagnosis.
  • The case highlights the need to consider epithelioid myxosarcoma in differential diagnoses for feline intraocular tumors and stresses the importance of early surgical intervention to prevent further complications.
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Article Synopsis
  • This study aimed to investigate the prevalence of pre-iridal monocellular and fibrovascular membranes in dogs with different types of glaucoma, and to explore how these membranes relate to factors like breed and age.
  • The research involved analyzing records of 108 dogs that had their eyes removed due to glaucoma, categorizing them into three groups based on the type of glaucoma.
  • Results indicated that monocellular membranes were most prevalent in primary glaucoma cases, while fibrovascular membranes were more common in secondary glaucoma; however, there were no links between membrane types and the dogs' breed, gender, or age.
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Article Synopsis
  • - Chronic and acute forms of anterior uveitis linked to juvenile idiopathic arthritis (JIA) show different characteristics, with chronic uveitis affecting younger females and acute uveitis predominantly impacting older males with enthesitis.
  • - The study explored a model of JIA-associated uveitis in rats inoculated with a specific peptide (MAA) to analyze its effects on ocular inflammation, arthritis, and inflammatory markers.
  • - Results revealed that all MAA-inoculated rats developed uveitis with specific ocular symptoms, but did not develop arthritis or ANA positivity, and there were no differences in outcomes based on the age or sex of the rats.
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Preface.

Vet Clin North Am Small Anim Pract

March 2023

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Canine eyelid masses (tumors) should include the differential clinical diagnoses of neoplasia and blepharitis. They have many common clinical signs including tumor, alopecia, and hyperemia. Biopsy and histologic examination remains the most effective diagnostic test to establish a confirmed diagnosis and appropriate treatment.

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A Review of Canine Episclerokeratitis and Scleritis.

Vet Clin North Am Small Anim Pract

March 2023

Episcleritis is synonymous with episclerokeratitis although the latter is most appropriate as the cornea is often affected as well as the episclera. Episcleritis is a superficial ocular disease characterized by inflammation of the episclera and conjunctiva. It responds most commonly to topical antinflammatory medications.

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Reports of glaucoma associated with anterior segment dysgenesis in dogs and cats are rare. Anterior segment dysgenesis is a sporadic, congenital syndrome with a range of anterior segment anomalies that may or may not result in congenital or developmental glaucoma within the first years of life. Specifically, the anterior segment anomalies that put the neonatal or juvenile dog or cat at high risk for the development of glaucoma are filtration angle and anterior uveal hypoplasia, elongated ciliary processes, and microphakia.

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Feline Glaucoma.

Vet Clin North Am Small Anim Pract

March 2023

Feline glaucoma is best categorized as either secondary, congenital and anterior segment dysgenesis associated, or primary. More than 90% of all feline glaucoma develops secondary to uveitis or intraocular neoplasia. The uveitis is usually idiopathic and assumed to be immune-mediated, whereas lymphosarcoma and diffuse iridal melanoma account for many of the intraocular neoplastic-induced glaucoma in cats.

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A muskox neonate () that died of starvation was diagnosed with congenital lenticular anomalies that included spherophakia and hypermature cataract associated with probable lens-induced lymphocytic uveitis and neutrophilic keratitis. Impaired sight as a result of cataract and associated inflammation likely contributed to abandonment and starvation, although maternal death cannot be excluded definitively. Ocular lesions, such as congenital cataracts and spherophakia in neonates, may be important factors affecting survival in free-ranging animals.

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Objectives: (i) To evaluate immunohistochemical labeling of pre-iridal monocellular and fibrovascular membranes and (ii) describe the light and scanning electron microscopic (SEM) characteristics of these membranes in glaucomatous and normal/control canine globes.

Materials And Methods: All globes were evaluated with light microscopy. Immunohistochemical labeling for CD18, Smooth muscle actin (SMA), and CD117 was completed on 40 canine globes with congenital/anterior segment dysgenesis-associated glaucoma (n = 10), primary/goniodysgenesis-associated glaucoma (n = 10), secondary glaucoma (n = 10), and normal/control globes (n = 10).

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Purpose: To compare the scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT), and fluorescein angiography (FA) findings in retrievers with a single unilateral circular retinal plaque to those of an English springer spaniel with bilateral retinal dysplasia.

Procedures: A retrospective record review identified three dogs with circular retinal plaques that underwent SLO and OCT; in two of the three dogs, FA was also completed. Morphologic changes, lesion measurements, and angiogram characteristics were documented.

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Cavernous sinus syndrome is a unique constellation of cranial nerve deficits occurring typically as a result of pathologic infiltration of the cavernous sinus, which is located in the lateral sellar compartment of the calvarium. This case report describes a polyneuropathy consistent with cavernous sinus syndrome as a result of a lesion outside of the cavernous sinus. The cat was presented with right internal and external ophthalmoplegia, loss of right corneal sensation, inspiratory stridor, dysphagia, dysphonia, tongue weakness, and weight loss.

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Horner's syndrome arises from dysfunction of the oculosympathetic pathway and is characterized by miosis, enophthalmos, protrusion of the third eyelid, and ptosis. It has been recognized in a wide variety of breeds and ages in small animal patients. The oculosympathetic pathway is a 3-neuron pathway.

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Purpose: To describe the optical coherence tomography (OCT) and fluorescein angiography changes in dogs with sudden acquired retinal degeneration syndrome (SARDS).

Methods: Retinal OCT was performed on 10 SARDS dogs and eight control dogs. Tomograms were collected in four quadrants around the optic nerve.

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A 11-year-old neutered male Labrador retriever-cross dog was presented to the University of Missouri-Columbia Veterinary Ophthalmology Service for subtle visual deficits. Indirect ophthalmoscopy revealed a smooth, bullous elevation in the superior-temporal retina OU. Optical coherence tomography (OCT) performed OU showed inner retinal separation consistent with retinoschisis.

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A novel case of a canine odontogenic parakeratinized cyst (COPC) that resulted in exophthalmos and palatine, maxillary, and zygomatic bone erosion in a 5-year-old Chihuahua dog is reported. Final diagnosis was aided by cross-sectional imaging (magnetic resonance imaging and computed tomography) and confirmed with histologic examination of the cyst wall.

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This study reviewed clinical data from dogs diagnosed with sudden acquired retinal degeneration syndrome (SARDS) in western Canada. Medical records from the Western College of Veterinary Medicine from 2002 to 2016 showed that 93 cases of SARDS were diagnosed based on presentation for sudden blindness and a bilaterally extinguished electroretinogram. The most common pure breeds were the miniature schnauzer, dachshund, and pug.

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We describe bilateral true anophthalmia in a juvenile female eastern gray squirrel (Sciurus carolinensis) with histologic confirmation that orbital contents lacked ocular tissues. Additionally, the optic chiasm of the brain was absent and axon density in the optic tract adjacent to the lateral geniculate nucleus was reduced.

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The objectives of this study were to determine the demographics of horses with equine recurrent uveitis (ERU) presenting to the Western College of Veterinary Medicine and to describe and compare the prognosis of ERU in the Appaloosa with that in other breeds. Horses diagnosed with ERU by a veterinary ophthalmologist between 2002 and 2015 were included. Eye lesions were classified as mild, moderate, or severe based on clinical manifestations.

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This report describes congenital nuclear cataracts and posterior lenticonus in a closed purebred Holstein dairy herd in Canada. Ophthalmic examinations were completed on 30 male and 249 female cattle aged newborn to 10 years old. Nutritional, infectious, and toxic etiologies were investigated.

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