Cranial osteology and neuroanatomy of the late Permian reptile and implications for early reptile evolution.

Millerettidae are a group of superficially lizard-like Permian stem reptiles originally hypothesized as relevant to the ancestry of the reptile crown group, and particularly to lepidosaurs and archosaurs. Since the advent of cladistics, millerettids have typically been considered to be more distant relatives of crown reptiles as the earliest-diverging parareptiles and therefore outside of 'Eureptilia'. Despite this cladistic consensus, some conspicuous features of millerettid anatomy invite reconsideration of their relationships.

Childhood Adversity and Telomere Length.

Exposure to adversity during childhood and adolescence is associated with numerous health conditions in adulthood; telomere shortening may be a mechanism through which adversity contributes to poor outcomes. We studied three areas of adversity (parent relational instability, child household instability, and financial instability) occurring during three epochs across childhood and adolescence and their associations with telomere length during adolescence. Data were obtained from the first wave of a longitudinal cohort study of youth aged 11-17 and their primary caregiver.

The osteohistology of Orthosuchus stormbergi using synchrotron radiation microcomputed tomography.

Orthosuchus stormbergi was a small-bodied crocodyliform, representative of a diverse assemblage of Early Jurassic, early branching crocodylomorph taxa from the upper Elliot Formation of South Africa. The life history of these early branching taxa remains poorly understood, with only sparse investigations into their osteohistology, yet species like Orthosuchus have potential to inform about the macroevolution of growth strategies on the stem leading to crown crocodilians. In order to elucidate the growth patterns of Orthosuchus, we used propagation phase contrast X-ray synchrotron micro-computed tomography to virtually image the osteohistology of the postcrania of two specimens, including multiple elements from the type (SAM-PK-K409), and the femur of a referred specimen (BP/1/4242).

Associations between adolescent perceived loneliness and hair cortisol concentration.

Introduction: Adolescents experience high levels of loneliness, which is linked to poor health in adulthood. Loneliness may contribute to poor health through chronic dysregulation of the hypothalamic-pituitary-adrenal axis. In this analysis, we examined the associations between survey- and ecological momentary assessment (EMA)-based measures of loneliness and hair cortisol concentrations (HCC) in a sample of 1102 adolescents and assessed sex differences in this relationship.

Relationship Between Family and Friend Support and Psychological Distress in Adolescents.

Objective: This study examines the associations between family and friend support and depressive and anxiety symptoms among adolescents, considering potential sex differences.

Methods: Secondary data from a longitudinal cohort study of 1,348 adolescents ages 11-17 were analyzed using descriptive statistics and multiple linear regression, controlling for relevant factors. Interaction terms between sex and support were created to examine moderation by sex.

Leveraging Experience Sampling/Ecological Momentary Assessment for Sociological Investigations of Everyday Life.

Experience sampling (ES) - also referred to as ecological momentary assessment (EMA) - is a data collection method that involves asking study participants to report on their thoughts, feelings, behaviors, activities, and environments in (or near) real time. ES/EMA is typically administered using an intensive longitudinal design (repeated assessments within and across days). Although use of ES/EMA is widespread in psychology and health sciences, uptake of the method among sociologists has been limited.

Child maltreatment and youth exposure to risky environments: Latent class analysis of youth activity spaces.

Background: Child maltreatment may alter the way that adolescents engage in and interact within the places they visit in their daily routines, namely youth activity spaces. Thus, it is important to understand how maltreatment experiences are linked to adolescents' exposure to environmental and contextual risks within their activity spaces.

Objective: The aim of the study was to explore the associations between child maltreatment and patterns of risk exposures within youth activity spaces among adolescents.

Exposure of Neighborhood Racial and Socio-Economic Composition in Activity Space: A New Approach Adjusting for Residential Conditions.

A longstanding urban sociological literature emphasizes the geographic isolation of city dwellers in residence and everyday routines, expecting exposures to neighborhood racial and socio-economic structure driven principally by city-wide segregation and the role of proximity and homophily in mobility. The compelled mobility approach emphasizes the uneven distribution of organizational and institutional resources across urban space, expecting residents of poor Black-segregated neighborhoods to exhibit non-trivial levels of everyday exposure to White, non-poor areas for resource seeking. We use two sets of location data in the hypersegregated Chicago metro to examine these two approaches: Global Positioning System (GPS) location tracking on a sample of older adults from the study and travel diaries on a sample of younger adults by the .

Fluorescence excitation-scanning hyperspectral imaging with scalable 2D-3D deep learning framework for colorectal cancer detection.

Colorectal cancer is one of the top contributors to cancer-related deaths in the United States, with over 100,000 estimated cases in 2020 and over 50,000 deaths. The most common screening technique is minimally invasive colonoscopy using either reflected white light endoscopy or narrow-band imaging. However, current imaging modalities have only moderate sensitivity and specificity for lesion detection.

Supporting Local Public Health and Planning Professionals to Implement Built Environment Changes: A Technical Assistance Program to Promote Physical Activity in Texas.

Built environment approaches that improve active transportation infrastructure and environmental design can increase physical activity. Funded by the Centers for Disease Control and Prevention, the Texas Department of State Health Services rejuvenated the Texas Plan4Health program from 2018 to 2023 to expand such approaches in Texas by providing technical assistance to teams of local public health professionals and planners to identify and implement projects connecting people to everyday destinations via active transport in their communities. However, the COVID-19 pandemic prompted Texas Plan4Health to modify the delivery of technical assistance to accommodate restrictions on travel and in-person gatherings.

LAND-USE FILTERING FOR NONSTATIONARY SPATIAL PREDICTION OF COLLECTIVE EFFICACY IN AN URBAN ENVIRONMENT.

Collective efficacy-the capacity of communities to exert social control toward the realization of their shared goals-is a foundational concept in the urban sociology and neighborhood effects literature. Traditionally, empirical studies of collective efficacy use large sample surveys to estimate collective efficacy of different neighborhoods within an urban setting. Such studies have demonstrated an association between collective efficacy and local variation in community violence, educational achievement, and health.

A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability.

Chromosome instability, a hallmark of lung cancer, is a driving mechanism for hexavalent chromium [Cr(VI)] carcinogenesis in humans. Cr(VI) induces structural and numerical chromosome instability in human lung cells by inducing DNA double-strand breaks and inhibiting homologous recombination repair and causing spindle assembly checkpoint (SAC) bypass and centrosome amplification. Great whales are long-lived species with long-term exposures to Cr(VI) and accumulate Cr in their tissue, but exhibit a low incidence of cancer.

Racial Differences in Activity Space Exposures and Everyday Perceptions of Safety Among Urban Youth.

Purpose: The everyday experience of safety promotes health and successful development during adolescence. To date, few studies have examined racial variation in the spatial determinants of in-the-moment perceived safety.

Methods: Drawing on data from the Columbus, Ohio-based Adolescent Health and Development in Context study (N = 1,405), we consider the influence of intraindividual variability in Global Positioning System-based exposure to both high-proportion White urban neighborhoods and neighborhood violence for the everyday location-based safety perceptions of Black and White youth (ages 11-17) as captured by ecological momentary assessment.

Hemorrhoidectomy: Does Age Make a Difference?

Background: Grade II and III hemorrhoids often require a multimodal approach that may ultimately culminate in surgical resection. Age and overall medical conditioning around the time of diagnosis can often impact the decision.

Objective: The objective of this study was to evaluate patients with a diagnosis of symptomatic grade II or grade III hemorrhoids and determine progression to hemorrhoidectomy based on age and the time interval between diagnosis and surgical intervention.

Maternally Derived Antibodies to Foot-and-Mouth Disease Virus Modulate the Antigenic Specificity of Humoral Responses in Vaccinated Cattle.

Vaccination is widely used to control foot-and-mouth disease (FMD), but maternal antibodies may interfere with the response to vaccination in calves. This study, conducted on a regularly vaccinated Malaysian dairy farm, aimed to optimise the vaccination regime by measuring the in vitro neutralising virus antibody responses of 51 calves before and after vaccination with a one or two dose vaccination regime starting at 2-7 months old. The presence of maternal antibodies was associated with poor post-vaccination antibody responses after a single dose of vaccine in calves less than 6 months old.

The Immunogenicity of a Foot-and-Mouth Disease Virus Serotype O Vaccine in Commercial and Subsistence Cattle Herds in Zambia.

The recent introduction of foot-and-mouth disease (FMD) virus serotype O (O/EA-2 topotype) in Southern Africa has changed the epidemiology of the disease and vaccine requirements of the region. Commercial and subsistence cattle herds in Zambia were vaccinated with an FMD virus serotype O Manisa vaccine according to a double- or single-dose vaccination schedule. Heterologous antibody responses induced by this vaccine against a representative O/EA-2 virus from Zambia were determined.

Association between longitudinal patterns of child maltreatment experiences and adolescent substance use.

Background: Although there is a well-established link between child maltreatment and adolescent substance use, it remains unclear if and how longitudinal patterns of maltreatment experiences are associated with substance use in adolescence.

Objective: The purpose of the study was to examine how distinct patterns of longitudinal maltreatment experiences are associated with adolescent substance use.

Participants And Setting: The participants were 899 adolescents from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN).

Transforming global approaches to chronic disease prevention and management across the lifespan: integrating genomics, behavior change, and digital health solutions.

Chronic illnesses are a major threat to global population health through the lifespan into older age. Despite world-wide public health goals, there has been a steady increase in chronic and non-communicable diseases (e.g.

The Social Environment Matters for Telomere Length and Internalizing Problems During Adolescence.

Depression and anxiety symptoms are on the rise among adolescents. With increasing evidence that cellular aging may be associated with depressive and anxiety symptoms, there is an urgent need to identify the social environment context that may moderate this link. This study addresses this research gap by investigating the moderating role of the social environment on the relation between telomere length and emotional health among adolescents.

Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension.

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.

Fabry-Pérot optical frequency comb based mm-wave RoF system using pilot-assisted equalizer.

The emergence of the millimeter wave (mm-Wave; 30 GHz to 300 GHz) frequency band holds a lot of promise for addressing the congestion at low frequency in future mobile networks. Among many mm-Wave generation schemes, optical heterodyning is considered one of the most promising approaches due to its scalability and potential for integration on chip. Employing optical frequency combs (OFC) for optical heterodyning alleviates the significant phase distortions/noise introduced by the optical sources.