Open-label, multicentre expansion cohort to evaluate imgatuzumab in pre-treated patients with KRAS-mutant advanced colorectal carcinoma.

Aim: Imgatuzumab (GA201) is a novel anti-epidermal growth factor receptor (anti-EGFR) antibody glycoengineered for enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). We investigated the efficacy of imgatuzumab in patients with EGFR-positive, KRAS-mutant advanced colorectal cancer.

Methods: Patients received single-agent imgatuzumab (1400mg on day 1 and 8 followed by q2W) as third line therapy in an open-label, multicentre, non-randomised, expansion study.

Investigation of the photoinduced magnetization of copper octacyanomolybdates nanoparticles by X-ray magnetic circular dichroism.

Through an extensive set of SQUID magnetic measurements, X-ray absorption spectroscopy, and X-ray magnetic circular dichroism, we have determined the nature of the metastable photomagnetic phase in the cyano-bridged 3D network Cs(2)Cu(7)[Mo(CN)(8)](4). The photomagnetic effect is induced by the photoconversion of Mo(IV) ions in low spin (LS) configuration (S = 0) into Mo(IV) ions in high spin (HS) configuration (S = 1). The magnetic and spectroscopic measurements fully support the LS to HS conversion, whereas the previously invoked charge transfer mechanism Mo(IV) + Cu(II) ⇒ Mo(V) + Cu(I) can be completely ruled out.

Characteristics of dextrin adsorption by elemental sulfur.

Characteristics of dextrin adsorption by elemental sulfur were investigated by the means of diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, total organic carbon (TOC) measurements, BET measurements as well as molecular dynamics simulation (MDS). Adsorption isotherms for dextrin adsorption by sulfur were compared to isotherms for dextrin adsorption by other hydrophilic and hydrophobic surfaces taken from the literature. The three-dimensional structure of dextrin was studied in detail and possible mechanisms of adsorption are discussed.

Boron neutron capture therapy: a mechanism for achieving a concomitant tumor boost in fast neutron radiotherapy.

Purpose: For many years neutron radiation has been used to treat malignant disease both as fast neutron radiotherapy and as thermal neutron induced boron neutron capture therapy (BNCT). To date, these two approaches have been used independently of one another due to the large difference in neutron energies each employs. In this paper we discuss the potential application of BNCT to enhance the therapeutic effectiveness of a fast neutron radiotherapy beam.