Arteriovenous differences for amino acids and lactate across kidneys of normal and acidotic rats.

1. Arteriovenous differences fro amino acids across kidneys of normal and chronically acidotic rats were measured. Glutamine was the only amino acid extracted in increased amounts in acidosis.

Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride.

1. The time-course of the changes in the concentrations of hepatic metabolites in response to a non-toxic load of NH(4)Cl were measured in fed and starved rats. 2.

Effects of metabolic acidosis and starvation on the content of intermediary metabolites in rat kidney.

1. Metabolite contents were determined in freeze-clamped kidney from acidotic and starved rats in order to elucidate the rate-controlling steps which are responsible for the acceleration of gluconeogenesis in these situations. 2.

Effects of ischaemia on content of metabolites in rat liver and kidney in vivo.

1. The time-course of changes in content of intermediates of glycolysis in rat liver and kidney cortex after severance of blood supply was investigated. 2.

Effects of ischaemia on metabolite concentrations in rat liver.

1. Changes in the concentrations of ammonia, glutamine, glutamate, 2-oxoglutarate, 3-hydroxybutyrate, acetoacetate, alanine, aspartate, malate, lactate, pyruvate, NAD(+), NADH and adenine nucleotides were measured in freeze-clamped rat liver during ischaemia. 2.