Publications by authors named "Brooke Verhaeghe"
Screening for inhibitors of microglia to reduce neuroinflammation.
CNS Neurol Disord Drug Targets
September 2013
Article Synopsis
- Researchers screened 1040 compounds to find inhibitors of microglia aimed at reducing neuroinflammation in multiple sclerosis (MS).
- Out of these, 123 compounds significantly lowered TNF-α levels in activated microglia, but most were found to be cytotoxic at the tested concentration.
- Spironolactone emerged as a promising candidate because it effectively reduced TNF-α without harming microglia or other CNS cells, suggesting potential for further therapeutic exploration in MS.