Publications by authors named "Brooke Hoppe"
Opioid use disorders (OUD) and overdoses are ever-evolving public health threats that continue to grow in incidence and prevalence in the United States and abroad. Current treatments consist of opioid receptor agonists and antagonists, which are safe and effective but still suffer from some limitations. Murine and humanized monoclonal antibodies (mAb) have emerged as an alternative and complementary strategy to reverse and prevent opioid-induced respiratory depression.
View Article and Find Full Text PDFChordoma is a rare malignant tumor demonstrating notochordal differentiation. It is dependent on brachyury (TBXT), a hallmark notochordal gene and transcription factor, and shares histologic features and the same anatomic location as the notochord. This study involved a molecular comparison of chordoma and notochord to identify dysregulated cellular pathways.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how specific peptide structures, particularly those favoring β-turns, influence the efficiency of aldol reactions using primary amine tetrapeptides as catalysts.
- Researchers modified certain amino acids in a lead tetrapeptide sequence to see how they impacted the β-turn structure and then assessed their correlation with the reaction's speed and selectivity.
- Results indicated a general link between the β-turn structure and reaction rates, but changes in the peptide had little effect on the stereoselectivity, providing insights for designing better catalysts in the future.