Tissue eosinophilia: not an indicator of drug-induced subacute cutaneous lupus erythematosus.

Objective: To investigate whether tissue eosinophilia is a differentiating histopathologic feature of drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) compared with non-DI-SCLE.

Design: Retrospective medical record review with prospective blinded histopathologic analysis.

Setting: University-affiliated dermatology and dermatopathology practice.

Oxalosis involving the skin: case report and literature review.

Background: The primary hyperoxalurias are a group of rare autosomal recessive metabolic disorders associated with abnormal overproduction of serum oxalate and subsequent deposition in tissue. Most patients present at an early age with recurrent urolithiasis and renal failure. Vascular deposition of oxalate-producing skin manifestations, such as livedo reticularis, acrocyanosis, peripheral gangrene, and ulcerations, is typical of the primary hyperoxalurias.