Publications by authors named "Brooke F Murray"
Article Synopsis
- Transgenesis is a key genetic technique, and the use of Tol2-based systems with Gateway vectors has improved zebrafish transgenesis, making it easier to use.
- The authors developed new tools for testing gene regulatory elements and expanded the color options for transgenic research by introducing vectors with various fluorophores.
- They also created specific transgenesis markers for the zebrafish pineal gland that work before and after hatching, which can be applied to other species like cavefish, enhancing the versatility of their transgenic applications.
Establishment of precise three-dimensional tissue structure is vital for organ function. In the visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood process, disruptions of which can lead to coloboma, a birth defect causing visual impairment. Here, we use four-dimensional imaging, cell tracking, and molecular genetics in zebrafish to define the cell movements underlying normal optic fissure and stalk formation.
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