Earth Observation Data to Support Environmental Justice: Linking Non-Permitted Poultry Operations to Social Vulnerability Indices.

Concentrated Animal Feeding Operations (CAFOs) apply massive amounts of untreated waste to nearby farmlands, with severe environmental health impacts of swine CAFOs and proximity to disadvantaged communities well documented in some US regions. Most studies documenting the impacts of CAFOs rely almost exclusively on CAFO locations known from incomplete public records. Poultry CAFOs generate dry waste and operate without federal permits; thus, their environmental justice (EJ) impacts are undocumented.

Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.

Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advance inhibitor potency and selectivity. Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands.