Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in .

Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid synthetase (CSAS) and sialyltransferase (SiaT) that mediate the activation of sialic acid and its transfer onto glycan termini, respectively. In , and genes function in the nervous system, affecting neural transmission and excitability.

Meta-Analysis of Immune Induced Gene Expression Changes in Diverse Innate Immune Responses.

Organisms are commonly infected by a diverse array of pathogens and mount functionally distinct responses to each of these varied immune challenges. Host immune responses are characterized by the induction of gene expression, however, the extent to which expression changes are shared among responses to distinct pathogens is largely unknown. To examine this, we performed meta-analysis of gene expression data collected from following infection with a wide array of pathogens.

is a non-lethal modifier of the mosaic eye phenotype in .

Genetic screens have been used to identify genes involved in the regulation of different biological processes. We identified growth mutants in a Flp/FRT screen using the eye to identify conditional regulators of cell growth and cell division. One mutant identified from this screen, , was mapped and characterized by researchers in undergraduate genetics labs as part of the Fly-CURE.