[The impact of fireworks: the context of facial trauma].

In the Netherlands the general public can legally use fireworks on New Year's Eve. Despite the fact that the public is well aware of the dangers of fireworks, fireworks accidents occur in which the victims suffer a variety of injuries. In addition to burns, injuries to fingers and/or hands are most common.

Are antineutrophil cytoplasmic antibody-associated vasculitides pauci-immune?

The role of ICs in ANCA-associated vasculitides remains controversial. The ANCA-associated vasculitides are described as being pauci-immune. We hypothesize that the absence of ICs is a result of an exaggerated inflammatory response caused by the presence of ANCAs.

Detection of immune deposits in skin lesions of patients with Wegener's granulomatosis.

Background: Wegener's granulomatosis (WG) is considered a pauci-immune systemic vasculitis based on the absence of immune deposits in renal biopsies of patients with active disease. In animal models of antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis, immune deposits along the glomerular capillary wall are present at early stages of lesion development. These deposits are degraded rapidly, resulting in "pauci-immune" lesions.

Staphylococcal acid phosphatase binds to endothelial cells via charge interaction; a pathogenic role in Wegener's granulomatosis?

The majority of patients with Wegener's granulomatosis (WG) are chronic nasal carriers of Staphylococcus aureus. Chronic nasal carriage of S. aureus is associated with an increased risk of developing a relapse of the disease.

Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids.

The present study was designed to elucidate the neurotransmitters involved in activation of the noradrenergic nucleus, locus coeruleus, by distention of the distal colon. Locus coeruleus spontaneous discharge rate was recorded from halothane-anesthetized rats before, during and after distention of the colon produced by inflation of a balloon catheter with varying volumes of water. Locus coeruleus activation by colon distention was volume-dependent and reversible.

[Harmony of the facial profile. Part IV. Sagittal rules].

Different inclines characterize the respective parts of the profile. These inclines are identified by the values of the angles created by the individual reference line and the lines representing the inclines. It is shown how these inclines should relate to achieve individual formal perfection of the profile.

[Harmony of the facial profile. Part III. Vertical rules].

Rules for profile harmony in the vertical direction reflect the acceptable relations between the heights of the different facial parts. The relation between the maxillary and nasal heights determines the acceptable range for the mandibular height.

[Harmony of the facial profile. Part II. The analysis].

Rules for harmony of the facial profile reflect the individual perfection of the whole profile. A system of coordinates can be obtained in the same manner in every individual, reflecting the individual form. These coordinates provide valid rules for individual application.

[Harmony of the facial profile. Part I. Introduction and concept definition].

The terms beauty, attractiveness and harmony can be brought together under the notion of esthetics. Harmony is the only notion to provide us with the possibility of formulating objective and generally applicable criteria for an acceptable facial profile. The prerequisites for these criteria are outlined.

Type of stressor and depressive mood in patients with rheumatoid arthritis.

The relationship of two types of stressors to depressive mood was investigated in 54 patients with rheumatoid arthritis. Depressive mood was associated with disease-related stressors (pain, effects of disease on daily activities) but was unrelated to major life events.

The supportive effects of IL-7 on eosinophil progenitors from human bone marrow cells can be blocked by anti-IL-5.

Human rIL-7 was studied for its effects on myeloid and erythroid progenitors from human bone marrow cells. IL-7 did not support the granulocytic/monocytic or erythroid lineage but exclusively stimulated eosinophil colony formation (CFU-Eo) (4 +/- 3 vs 48 +/- 17 CFU-Eo/10(5) nonadherent fraction-non-T cell (NAF-NT) cells). This supportive effect was not mediated by T cells or monocytes because similar results were obtained with or without T cell or adherent depleted cell fractions.

In vitro evaluation of a high-efficiency leukocyte adherence filter.

In view of the currently available data, prevention of alloimmunization requires filters with higher efficiency to achieve a reduction in the number of leukocytes below 10 million per transfusion. Two versions (Pall PL-100 and PL-50) of the new generation leukocyte-depletion filters were studied. Single donor (SDPC)- and pooled multiple donor (MDPC) platelets were run in parallel.

[Glass ionomer cement used as a retrograde filling material after apicoectomy: a review].

When an apicoectomy is performed, using retrograde sealing with amalgam, the healing of the periapical area is not always perfect. In a number of cases the cause of this imperfect healing may be due to the improper sealing ability and the moderate tissue compatibility of amalgam. A literature study has been carried out, based on the assumption that glass ionomer cement will provide a better sealing and will cause less tissue reaction.

Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell.

We have studied the in vivo spleen colony-forming ability and marrow repopulating ability of murine bone marrow cells differing in mitochondrial activity. Following centrifugal elutriation the cells were sorted on the basis of rhodamine-123 fluorescence intensity within a predetermined light scatter window. It is shown that a class of hemopoietic stem cells exists that differs from the majority of day-12 spleen colony-forming units (CFU-S) in that it has low mitochondrial activity and a high capacity to generate in time new day-12 CFU-S and cells that rescue recipients from radiation-inflicted death.

Bulk enrichment of transplantable hemopoietic stem cell subsets from lipopolysaccharide-stimulated murine spleen.

Counterflow centrifugal elutriation (CCE) in combination with density flotation centrifugation and fluorescence-activated cell sorting on wheat-germ agglutinin-FITC(WGA)-binding cells within the light-scatter "blast window" were used consecutively to enrich pluripotent hemopoietic stem cells (HSC) in bulk from lipopolysaccharide-stimulated mouse spleen. The medium-to-strong WGA + ve fraction contained 3.10(6) cells isolated from 3-4 X 10(9) spleen cells, with an average of 126% day-12 CFU-S and 65% day-8 CFU-S as calculated on the basis of their seeding fraction, suggesting that virtually all cells represented in vivo macroscopic colony formers.

A comparative study of myocardial infarct detection using Tc99m pyrophosphate and In111 DTPA antimyosin (R11D10 Fab).

A crossover study to examine the potential of In111 antimyosin Fab fragment to detect fresh myocardial infarcts in comparison with Tc99m pyrophosphate is reported. In 27 cases indium antimyosin correctly diagnosed 19 patients with infarcts and 4 true negatives. There were also 2 false positive and 2 false negative scintigrams.

The response of Slj/+ mice to experimental manipulation of the erythron.

We have compared the response of mice heterozygous for the Slj allele-which have a stromal defect resulting in mild macrocytic anemia-and their normal +/+ littermates to manipulations of the erythron to further characterize the effects of the Slj allele on hemopoiesis. CFU-S kinetics in Slj/+ mice following plethorization or induction of anemia did not differ from similarly treated +/+ littermates. Under all circumstances, however, Slj/+ mice had a smaller splenic CFU-S population than similarly treated +/+ mice.

Treatment of mandibular fractures by means of stable internal wire fixation.

Treatment according to the principles of stable internal fixation offers great advantages for fractures of the mandibular body. Most authors believe that a stable internal fixation can be achieved only by means of bone plating or screw fixation. At Groningen a wire connection was designed by BRONS which could be considered to be stable.

Visor osteotomy and vestibuloplasty--a one-stage procedure. A preliminary report.

The visor osteotomy as described by HARLE gives a considerable increase of the absolute height of the atrophic mandible, between the mental foramina. After 6 weeks a total vestibuloplasty with mucosal grafting (and a lowering of the floor of the mouth) is performed. A method is described in which the visor osteotomy and the vestibuloplasty are performed in one stage.

Operative treatment of arthrosis deformans of the temporomandibular joint: a preliminary report.

If patients with arthrosis deformans of the temporomandibular joint are treated without success by conservative means, operative therapy may be indicated. The type of operation depends on the complaints: a)resection of the auriculotemporal nerve and superficial temporal artery; or b) the same operation in combination with condylar shaving. Twenty-four joints in 14 patients underwent a denervation.