Publications by authors named "Bronge M"
Multiple sclerosis (MS) is a prototypical autoimmune disease of the central nervous system (CNS). In addition to CD4 T cells, memory B cells are now recognized as a critical cell type in the disease. This is underlined by the fact that the best-characterized environmental risk factor for MS is the Epstein-Barr virus (EBV), which can infect and persist in memory B cells throughout life.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which and Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between Epstein-Barr nuclear antigen 1 (EBNA1) and alpha-crystallin B (CRYAB), we examined antibody reactivity to EBNA1 and CRYAB peptide libraries in 713 persons with MS (pwMS) and 722 matched controls (Con). Antibody response to CRYAB amino acids 7 to 16 was associated with MS (OR = 2.
View Article and Find Full Text PDFArticle Synopsis
- Multiple sclerosis (MS) is an inflammatory disease affecting the central nervous system, with autoimmune T cells playing a key role in its pathology.
- Researchers identified four new autoantigens linked to MS, expanding the understanding of immune responses in the disease.
- The study highlights the diversity of T cell responses and suggests potential targets for future MS diagnostics and treatments.
Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS.
Acta Neuropathol Commun
November 2020
Article Synopsis
- Autoimmune disorders of the central nervous system (CNS) are diverse, and understanding the specific autoantigens is crucial for improving therapy and understanding disease causes.
- Researchers studied oligodendrocyte myelin glycoprotein (OMGP) as a potential autoimmune target and found autoantibodies to OMGP in a small percentage of multiple sclerosis patients, a child with encephalomyelitis, and one patient with psychosis, but not in healthy controls.
- The presence of OMGP-specific T cells in an animal model led to a new type of experimental autoimmune encephalomyelitis characterized by unusual inflammation, emphasizing the role of OMGP in patient diagnostic and therapeutic stratification.
Reliable and sensitive detection of antigen specific cells is essential in several fields of research, whether it concerns monitoring responses to infectious agents or exploring the auto-antigen repertoire in autoimmune diseases. Identification of these cells is however difficult, especially when the cells often are rare and methods not sensitive, specific or practical enough. We propose a novel method of processing antigens before stimulation of cells which consists of covalently binding protein antigen to superparamagnetic micro-beads and using denaturing washes to remove contaminants.
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- Autoreactive CD4 T-cells play a significant role in driving multiple sclerosis (MS), with myelin oligodendrocyte glycoprotein (MOG) being a key autoantigen, although its significance has been questioned due to low detection rates.
- This study utilized a novel method with bead-bound MOG to analyze T-cell reactivity and found that a higher frequency of MOG-specific T-cells producing cytokines (IFNγ, IL-22, IL-17A) was present in individuals with MS compared to healthy controls.
- Approximately 46.2-59.6% of MS patients exhibited MOG-reactivity, and blocking specific immune cells eliminated this response, indicating that MOG
Background: Dog dander extract used for diagnosis and allergen-specific immunotherapy is often of variable and of poor quality.
Objective: To assemble four well-established dog allergen components into one recombinant folded protein for improved diagnosis and vaccination of allergy to dog.
Methods: A linked molecule, comprising the four dog lipocalin allergens Can f 1, Can f 2, Can f 4 and Can f 6 was constructed.
We evaluated the effects of concentric simultaneous vision bifocal contact lenses on task performance, visual acuity, and stereopsis. Forty extensively screened presbyopes were fitted with CIBA Spectrum center-near bifocal contact lenses (BCL) and with distant contact lenses combined with reading spectacles (DCL) which served as the control. Thirty-two subjects completed the 8-week study.
View Article and Find Full Text PDFWe evaluated the visual results and success rate with a center-near concentric simultaneous vision bifocal contact lens. Forty subjects (screened from 175 presbyopic applicants) entered the study and were fitted with the CIBA Spectrum bifocal lenses (BCL) and also with single vision distance contact lenses combined with reading glasses (DCL). Visual acuity and stereoacuity measurements were made at dispensing and after 8 weeks of regular bifocal contact lens wear.
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