Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study.

A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed using binary and ternary mixtures, and samples were stored for 3 and 6 months at 40°C under 75% relative humidity and dry conditions.

Effects of cadmium and copper biosorption on Chlorella vulgaris.

Changes in protein levels and lipid compositions in algal cells indicate the severity of stress related to toxic concentrations of heavy metals. In this study, the effects of exposure to cadmium and copper on Chlorella vulgaris and its capacity to remove metals were evaluated. The data revealed ion removal activity by microalgae under all treatments and different levels of protein expression after 48 h of exposure.

A single FIA system coupled with reduction and distillation processes for the determination of sulfate ion by spectrophotometry.

In the present work, all steps of the sulfate reduction procedures, such as reduction, distillation and sulfate determination were joined in only one FIA system. The formed sulfide was on-line determined by employ the Fisher reaction. The proposed method presented a LOD of 1.

Direct introduction of water sample in multisegmented flow-injection analysis for sulfide determination.

The present paper describes an inline flow-injection analysis system for the determination of sulfide in water samples, exploiting the Fischer reaction. Water samples were collected and introduced into a reactor of the FIA system. The sulfide released, after sample acidification, was carried out with a nitrogen gas flow and mixed with N,N diethyl-p-phenylenediamine (DEPD) solution in the presence of Fe(III).