Publications by authors named "Brody A Flanagin"

Purpose: Arthroscopic transosseous (TO) rotator cuff repair has recently emerged as a new option for surgical treatment of symptomatic rotator cuff tears. Limited data is available regarding outcomes using this technique. This study evaluated midterm clinical outcomes following a novel arthroscopic TO (anchorless) rotator cuff repair technique.

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Background: The treatment of young patients with glenohumeral arthritis has been challenging. Alternative treatment options include activity modification, arthroscopic débridement, and arthroplasty. Addressing the glenoid during arthroplasty in this population of patients continues to be a significant challenge.

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Percutaneous radiofrequency ablation (RFA) has been increasingly used in the treatment of osteoid osteoma (OO), as this method has provided satisfactory results with minimal morbidity. RFA traditionally has been performed by radiologists under computed tomography (CT) guidance. Advances in intraoperative imaging techniques now allow orthopedic oncologists to perform image-guided RFA in the operating room.

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Purpose: To describe outcomes after surgical management of pediatric elbow dislocation with incarceration of the medial epicondyle.

Methods: We conducted a retrospective case review of 11 consecutive children and adolescents with an incarcerated medial epicondyle fracture after elbow dislocation. All patients underwent open reduction internal fixation using a similar technique.

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Hip dislocation secondary to developmental dysplasia of the hip is a debilitating condition. Total hip arthroplasty has proven successful in improving pain, restoring joint function, and correcting leg length discrepancies in this select population. Various techniques have been developed to address the increased complexity inherent to the reconstruction of the severely dysplastic hip.

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Scapulothoracic dissociation is rare, resulting from high-energy trauma to the shoulder girdle and disruption of the scapulothoracic articulation. The associated musculoskeletal, vascular, and neurologic injuries carry potentially devastating outcomes. Overall outcomes seem to be closely related to the degree of neurologic impairment sustained.

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Coronal shear fractures of the femoral condyle (ie, Hoffa fracture) are an uncommon clinical entity typically seen in adults after higher-energy trauma. Historically poor outcomes have been reported in the literature with nonoperative treatment of these fractures. Conversely, open reduction and internal fixation of these fractures has been shown to produce good long-term clinical results in adults.

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  • - Bariatric surgery can change stomach anatomy, leading to hiatal hernias and gastroesophageal reflux disease (GERD), which may result in severe heartburn and unusual symptoms, even if many patients feel fine.
  • - A study at a US hospital detailed four cases where patients experienced extreme midepigastric pain, nausea, and vomiting after undergoing surgery, but routine tests didn't identify the cause.
  • - Advanced imaging techniques finally diagnosed hiatal hernias in all cases, and surgery successfully relieved their debilitating symptoms, highlighting the need for timely surgical intervention in similar situations.
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  • Genetic factors contribute to addiction, but no specific genes have consistently been linked to drug use or abuse.
  • The study focuses on the Brain-derived neurotrophic factor (BDNF) gene, particularly the G196A (val66met) variant, and its effects on responses to d-amphetamine (AMPH).
  • Results showed that participants with the val/met and met/met genotypes reported less arousal and energy but had a greater increase in heart rate after taking AMPH compared to those with the val/val genotype, indicating a potential link between BDNF and the effects of amphetamine.
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  • - A missense polymorphism in the mouse nicotinic receptor alpha4 subunit gene (Chrna4) results in an amino acid change (Ala/Thr) at position 529, which is linked to varying sensitivity to nicotine among different mouse strains.
  • - The study reveals that the alpha4 subunit's T529 variant interacts differently with the beta2 subunit, showing reduced sensitivity to blockade and higher thresholds for activation compared to the A529 variant.
  • - Findings indicate that this polymorphism affects receptor function by altering the balance between high and low affinity receptor populations, suggesting a new functional domain in the alpha4 subunit that is critical for nicotine response.
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