The metabolic effects of acute and chronic administration of gastrozepin.

The structure of gastrozepin (G) resembles that of tricyclic antidepressants and antihistaminic and antiserotonic cyproheptadine which are compounds with known metabolic effects. The object of this study was to test the potential action of G on the metabolism of basic nutrients, insulin and selected hormonal parameters after parenteral administration (10 and 20 mg G) and after chronic oral administration (50 mg G) during antiulcer therapy. Investigations carried out in two groups of 7 and 9 healthy volunteers, respectively, and on one group of seven patients with ulcer disease, revealed no changes in any of the blood parameters studied, nor in the excretion of catecholamines or 17-OH steroids in the urine.

Circadian rhythms of urinary sodium, potassium and some agents influencing their excretion in young borderline hypertensives.

The circadian rhythms of sodium (Na+), potassium (K+), aldosterone (ALDO), 11-deoxycorticosterone (DOC), 18-hydroxy-DOC (18-OH-DOC), cortisol (F), corticosterone (B), adrenaline (A), noradrenaline (NA), dopamine (DA), metanephrine (MN), normetanephrine (NMN), homovanillic acid (HVA), kallikrein (KE) and prostaglandins E (PGE) and F2 alpha (PGF2 alpha) excretion were studied in eight young borderline hypertensive men (BHT) and in six healthy age-matched normotensive subjects (NT) during hospitalization, after adaptation to the hospital regimen and a diet containing 135 mmol Na+ and 90 nmol K+. Urine samples were collected in 4 h periods for 24 h: 1. at normal daily activity, 2.

Effect of sleep deprivation on cholesterol metabolism and triglyceridaemia in male volunteers.

The effect of 5-day sleep deprivation (SD) on cholesterol metabolism, together with triglyceridaemia, was studied in seven healthy male volunteers. A 3-day control period was followed by 5 days (120 h) complete SD and 4 days recovery. Blood was collected at 9 a.

Changes in the EEG spectrum at a two-week intensive endurance training.

Marathon runners in the course of a two-week endurance training, (i.e. in the beginning, after one and after two weeks) and processed by the off-line method of fast spectral analysis.

Importance of investigation of myocardial metabolites in diagnosis and evaluation of treatment of ischaemic heart disease.

Myocardial metabolism was examined in 114 patients with ischaemic heart disease. In selected subgroups, possibilities were detected of using this method in clinical cardiological diagnostics for determining or defining more precisely the diagnosis of ischaemic heart disease, and for objective evaluation of conservative or surgical therapeutic approach in ischaemic heart disease.

The effect of five days' fasting on skeletal muscle enzymes in obese men.

The effect of 120 hours' (five days) fasting on the activity of some enzymes of energy metabolism in skeletal muscles was investigated in six obese young men. The results revealed a significant decline in the activity of the following enzymes: triosophosphate dehydrogenase (by 20%), glycerol-3-phosphate dehydrogenase (by 24%), lactate dehydrogenase (by 13%), citrate synthase (by 20%), hydroxyacyl-CoA dehydrogenase (by 40%), while the hexokinase and malate dehydrogenase activities were not significantly altered. Contrary to muscles of non-obese healthy men (Vondra, Bass, Brodan, Kuhn, Andĕl, Veselková and Vítek 1982), a smaller decline of activities of the investigated enzymes occurred together with a paradoxical change of the enzyme pattern, namely a predominance of carbohydrate catabolism and a decline of the role of fatty acids in muscle energy metabolism.

The effect of glucagon on myocardial metabolism in diagnostic cardiac pacing.

Nine patients with the angina pectoris syndrome in the absence of a history of demonstrable myocardial infarction were examined twice at rest and during cardiac pacing at 13-min intervals. Glucagon (0.5 mg/50 ml saline) was applied before the second examination.

The effect of stress on circadian rhythms.

The authors chose four types of intensive stress in man and show their effect on the circadian rhythms of selected parameters. Sleep deprivation reduces mean sideraemia and oscilation amplitudes. The morning rhythm maximum shifts to early morning hours.

Changes in the circadian rhythm of serum iron induced by a 5-day sleep deprivation.

The effect of 5 days of sleep deprivation on the circadian rhythm of serum iron was studied in a group of six healthy male volunteers. The results were compared with a control group of five individuals, whose normal sleep cycle was preserved, but whose daily regimen was otherwise identical with the sleep deprivation group. Their biorhythm was processed mathematically using cosinor analysis.