A Selective Single Step Amidation of Polyfluoroarenes.

This chemistry establishes a method for the synthesis of per- and poly-fluoroaryl acid amides, utilizing nucleophilic aromatic substitution. Traditionally, such amides are constructed in a two-step process, namely, ammonolysis and then -acylation. Herein, good yields of polyfluoroaryl acid amides were achieved in a single step under mild reaction conditions.

Solubility of Iridium and Ruthenium Organometallic Photoredox Catalysts.

Despite the exponential growth of the field of photocatalysis, for reasons that are not entirely clear, these precious photocatalysts are often used in the literature at loadings that exceed their maximum solubility. On an industrial scale, the quantity of any precious metal catalyst can be a substantial financial burden or a sourcing issue, not to mention concerns as to the ecological and earth abundance of these catalysts. We believe that inattention to solubility has made these reactions appear less efficient than they actually are, because much of the photocatalyst remains undissolved.