Publications by authors named "Brock A Flores"
Purpose: A positron emission tomography (PET) tracer for the enzyme phosphodiesterase 10A (PDE10A) is desirable to guide the discovery and development of PDE10A inhibitors as potential therapeutics. The preclinical characterization of the PDE10A PET tracer [(11)C]MK-8193 is described.
Procedures: In vitro binding studies with [(3)H]MK-8193 were conducted in rat, monkey, and human brain tissue.