Publications by authors named "Broc Drury"
Article Synopsis
- FPR-1 is a special receptor in our body's immune system that detects signals from bacteria and other harmful substances, helping to start an immune response.
- Researchers studied how this receptor is involved in inflammatory bowel disease (IBD), which causes painful swelling in the intestines.
- They found that FPR-1 is more active in patients with IBD, and this can affect how well they respond to treatments, meaning it might be a good target for new therapies.
Background And Aims: Inflammatory bowel disease (IBD) is associated with increased circulating damage-associated molecular patterns, in particular, the highly pro-inflammatory mitochondrial DNA (mtDNA). Here, we study the importance of blood neutrophils in mtDNA release via neutrophil extracellular trap (NET) formation and mitochondrial NETosis, where neutrophils specifically expulse mtDNA as potential targetable biological pathways.
Methods: We investigated the roles of A23187 (a known NET stimulant), granulocyte macrophage stimulating factor, lipopolysaccharide (LPS), and human IBD plasma in their ability to induce NET formation, mitochondrial NETosis, mtDNA, and total DNA release from human blood neutrophils; and the evidence for increased NET formation in IBD.
Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation.
Cell Mol Gastroenterol Hepatol
June 2021
The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn's Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation involving innate and adaptive immune responses. Neutrophils, usually regarded as first responders in inflammation, are a key presence in the gut mucosal inflammatory milieu in IBD. Here, we review the role of neutrophil extracellular trap (NET) formation as a potential effector disease mechanism.
View Article and Find Full Text PDF