Twenty-Four-Month OCTA Assessment in Diabetic Patients Undergoing Fixed-Interval Intravitreal Aflibercept Therapy.

Background And Objective: Evaluate capillary perfusion density (CPD) in patients with diabetic macular edema (DME) undergoing fixed intravit-real aflibercept injections (IAI) through 24 months.

Patients And Methods: Prospective, interventional, single-arm study enrolling 20 patients with persistent DME. Patients received IAI every 4 weeks until DME resolution followed by extension to every 8 weeks.

Hickam's Dictum: Pseudoxanthoma elasticum and Usher syndrome in a single patient.

Background: To report the case of a patient with two distinct genetic systemic diseases - pseudoxanthoma elasticum (PXE) and Usher syndrome - confirmed by genetic testing.

Materials And Methods: Single Retrospective Case Report.

Results: A 36-year-old woman presented with acute central vision loss of the left eye (OS).

Discontinuation and nonpublication of interventional clinical trials conducted in ophthalmology.

Objective: Discontinuation of interventional clinical trials and nonpublication of completed trials represent a waste of already scarce resources. We sought to identify the prevalence of discontinuation and nonpublication of interventional clinical trials conducted in ophthalmology patients.

Methods: A retrospective, cross-sectional study of ophthalmology-based interventional clinical trials in ClinicalTrials.

Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder.

Purpose: Neonatal-onset Multisystem Inflammatory Disorder (NOMID) is a systemic syndrome characterized by rash, large joint osteoarthropathies and chronic meningitis. Ocular manifestations include optic disc edema, corneal opacities and uveitis. We report the novel finding of serous retinal detachments (RD) in NOMID.

Unilateral Birdshot Chorioretinopathy in an Elderly Patient.

[Full article available at http://rimed.org/rimedicaljournal-2019-02.asp].

Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.

We present the novel finding of retinal astrocytoma in a 15-year-old boy with phosphatase and tensin homologue hamartoma tumor syndrome, confirmed by genetic testing.

Man with a Swollen Eye: Nonspecific Orbital Inflammation in an Adult in the Emergency Department.

Background: Nonspecific orbital inflammation (NSOI) is a rare idiopathic ocular pathology characterized by unilateral, painful orbital swelling without identifiable infectious or systemic disorders, which can be complicated by optic nerve compromise.

Case Report: A 50-year-old man presented to the Emergency Department with recurring, progressive painless left eye swelling, decreased visual acuity, and binocular diplopia in the absence of trauma, infection, or known malignancy. His physical examination was notable for left-sided decreased visual acuity, an afferent pupillary defect, severe left eye proptosis and chemosis, and restricted extraocular movements; his dilatated funduscopic examination was notable for ipsilateral retinal folds within the macula, concerning for a disruption between the sclera and the retina.