Bridging Gaps: Creating a Digital Toolkit to Support Pregnant and Parenting Youth.

Despite declines in teen pregnancy, pregnant teens remain at risk for poor health and educational outcomes due to a lack of care coordination and access to resources. The purpose of this project was to develop and launch a care coordination toolkit to provide resources to pregnant and parenting youth (PPY) at a large urban school district. School personnel were trained on the use of the toolkit and completed pre- and posttraining surveys to evaluate changes in knowledge and confidence.

Silyl- and Germyl-Substituted Boranes: Synthesis and Investigation as Potential Atomic Layer Deposition Precursors.

Boranes featuring bulky hypersilyl or supersilyl groups and/or sterically unencumbered trimethylgermyl substituents were synthesized for investigation as potential precursors for atomic layer deposition (ALD) of elemental boron. The envisaged ALD process would employ a boron trihalide coreactant, exploiting the formation of strong silicon-halogen and germanium-halogen bonds as a driving force. The alkali metal silyl and germyl compounds hypersilyl lithium, {(MeSi)Si}Li(THF) (), supersilyl sodium, (BuSi)Na(THF) (, = 2-3), and trimethylgermyl lithium, {MeGeLi(THF)} (), were used for the synthesis of the silyl- and germyl-substituted boranes in this work.

Effective doses of scout projections in maxillofacial cone beam computed tomography.

Objectives: To assess the effective and organ/tissue equivalent radiation doses of different scout projection protocols in four CBCT units.

Methods: Optically stimulated luminescence dosimeters (OSLD) were placed in reference anatomical locations in the head and neck segments of an anthropomorphic phantom representing an average adult male. Ten repeated exposures were obtained from each of the twelve scout projections studied, acquired from four maxillofacial cone beam computed tomography (CBCT) units (Midmark EIOS, 3D Accuitomo F170, Veraviewepocs 3D R100, and Veraview X800).

An unusual ionic cocrystal of ponatinib hydrochloride: characterization by single-crystal X-ray diffraction and ultra-high field NMR spectroscopy.

This study describes the discovery of a unique ionic cocrystal of the active pharmaceutical ingredient (API) ponatinib hydrochloride (), and characterization using single-crystal X-ray diffraction (SCXRD) and solid-state NMR (SSNMR) spectroscopy. is a multicomponent crystal that features an unusual stoichiometry, with an asymmetric unit containing both monocations and dications of the ponatinib molecule, three water molecules, and three chloride ions. Structural features include (i) a charged imidazopyridazine moiety that forms a hydrogen bond between the ponatinib monocations and dications and (ii) a chloride ion that does not feature hydrogen bonds involving any organic moiety, instead being situated in a "square" arrangement with three water molecules.

Simvastatin induces degradation of the extracellular matrix in human leiomyomata: novel in vitro, in vivo, and patient level evidence of matrix metalloproteinase involvement.

Objectives: To assess the effect of simvastatin on uterine leiomyoma growth and extracellular matrix (ECM) deposition.

Design: Laboratory analysis of human leiomyoma cell culture, xenograft in a mouse model, and patient tissue from a clinical trial.

Setting: Academic research center.

A comparison of the coordination behaviour of RPCHBMe (R = Me Ph) ambiphilic ligands with late transition metals.

A new synthesis that avoids the use of MePH is reported for (MePCHBMe), and this method was extended to the synthesis of (PhPCHBMe). The ligand precursor (MePCHBMe) did not react with [{M(μ-Cl)(cod)}] (cod = 1,5-cyclooctadiene; M = Ir and Rh) or [PtCl(cod)] at room temperature. However, after 12-48 hours at 65-70 °C, these reactions afforded (a) [Ir(cod)(μ-Cl)(MePCHBMe)] (1), (b) an equilibrium mixture of (MePCHBMe), [{Rh(μ-Cl)(cod)}] and [Rh(cod)(μ-Cl)(MePCHBMe)] (2), and (c) -[Pt(μ-Cl)(MePCHBMe)] (3), respectively.

Reactions of [(dmpe)MnH(CH)] with hydrogermanes to form germylene, germyl, hydrogermane, and germanide complexes.

Reactions of the ethylene hydride complex -[(dmpe)MnH(CH)] (1) with secondary hydrogermanes HGeR at 55-60 °C afforded the base-free terminal germylene hydride complexes -[(dmpe)MnH(GeR)] (R = Ph; 2a, R = Et; 2b). Room temperature reactions of 2a or 2b with an excess of the primary hydrogermanes HGeR' (R' = Ph or Bu) afforded -[(dmpe)MnH(GeHR')] (R' = Ph; 3a, R' = Bu; 3b) in rapid equilibrium with small amounts of 2a/b, as well as the digermyl hydride complex -[(dmpe)MnH(GeHR')] {R' = Ph (4a) or Bu (4b)} and the -hydrogermane germyl complex -[(dmpe)Mn(GeHR')(HGeHR')] {R' = Ph (5a) or Bu (5b)}. Pure 3b was isolated from the reaction of 2b with HGeBu, whereas 3a decomposed readily in solution in the absence of free HGePh, and a pure bulk sample was not obtained.

An Unusual Macrocyclic Hexamer of an Iso-Tellurazole N-Oxide Featuring CTe O Chalcogen Bonds is Formed by κ -O Complexation to Fe(II) and Ni(II).

Studies of the supramolecular chemistry of iso-tellurazole N-oxides have been confined to non-polar media until now. To overcome that limitation, an iso-tellurazole N-oxide was derivatized with a primary alcohol group; the compound is soluble in polar solvents and stable in acidic to neutral aqueous media. Nickel (II) and iron (II) form macrocyclic complexes with six molecules of that iso-tellurazole N-oxide in a hitherto not-observed macrocyclic arrangement defined by CTe⋅⋅⋅O chalcogen bonds and κ -O bound to the metal ion.

Title IX Experiences of Pregnant and Parenting Youth in Chicago: A Qualitative Study.

Background: Under Title IX, pregnant and/or parenting students (PPY) are protected from discrimination and are required to receive equal access to education. This study examines the implementation of Title IX, investigating whether Title IX rights are upheld for pregnant and/or parenting students attending Chicago Public Schools (CPS) using qualitative research methods.

Methods: Stakeholder interviews with pregnant and/or parenting students and staff members at CPS were conducted.

Uranium(iv) alkyl cations: synthesis, structures, comparison with thorium(iv) analogues, and the influence of arene-coordination on thermal stability and ethylene polymerization activity.

Reaction of [(XA)U(CHSiMe)] (1; XA = 4,5-bis(2,6-diisopropylanilido)-2,7-di--butyl-9,9-dimethylxanthene) with 1 equivalent of [PhC][B(CF)] in arene solvents afforded the arene-coordinated uranium alkyl cations, [(XA)U(CHSiMe)(η -arene)][B(CF)] {arene = benzene (2), toluene (3), bromobenzene (4) and fluorobenzene (5)}. Compounds 2, 3, and 5 were crystallographically characterized, and in all cases the arene is π-coordinated. Solution NMR studies of 2-5 suggest that the binding preferences of the [(XA)U(CHSiMe)] cation follow the order: toluene ≈ benzene > bromobenzene > fluorobenzene.

Curcumin inhibits human leiomyoma xenograft tumor growth and induces dissolution of the extracellular matrix.

Objective: To determine whether a curcumin-supplemented diet would prevent and/or treat uterine leiomyoma growth in our mouse xenograft model.

Design: Animal study.

Setting: Laboratory study.

Coordination chemistry and structural rearrangements of the MePCHAlMe ambiphilic ligand.

Reaction of 2 equivalents of (MePCHAlMe) with [{RhCl(cod)}] (cod = 1,5-cyclooctadiene) afforded [{κ,-(MeAl)ClMeAl(CHPMe)}Rh(cod)] (1), which features a κ-coordinated bis(phosphino)aluminate anion. In compound 1, an Al-Cl substituent bridges to a molecule of AlMe, which could be removed to provide [{κ,-ClMeAl(CHPMe)}Rh(cod)] (2). By contrast, reaction of 1 equiv.

Relugolix and elagolix directly inhibit leiomyoma extracellular matrix production in 2-dimesnional and 3-dimensional cell cultures.

Objective: To determine the effect relugolix and elagolix have on the production of extracellular matrix (ECM) proteins in human leiomyoma cells.

Design: Laboratory study.

Setting: University hospital.

Carcinoembryonic antigen-related cell adhesion molecule 1: a key regulatory protein involved in leiomyoma growth.

Objective: To assess and characterize the role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in the development of uterine leiomyoma.

Design: Laboratory study.

Setting: Academic research center.

Three-dimensional human leiomyoma xenografts induce angiogenesis by inducing hypoxia inducible factor-1 alpha.

Objective: To characterize the method by which angiogenesis occurred in three-dimensional (3D) leiomyoma xenografts, and to assess the impact of hypoxia on two-dimensional (2D) and 3D myometrial and leiomyoma cells and leiomyoma xenografts in vivo.

Design: Laboratory study.

Setting: Academic research.

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A.

The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with distorted octahedral geometry. We report the solid-phase synthesis of 23 novel analogs of AMA involving structural diversification of each subunit (l-Asp, l-APA1, and l-APA2).

Iso-Tellurazolium-Phenoxides: A Family of Te···O Chalcogen-Bonding Supramolecular Building Blocks.

Formal substitution of the oxygen atom of an iso-tellurazole -oxide with deprotonated (, , and )-hydroxyphenyl groups generated molecules that readily aggregate through Te···O chalcogen bonding (ChB) interactions. The molecules undergo autoassociation in solution, as shown by variable temperature (VT) H NMR experiments and paralleling the behavior of iso-tellurazole -oxides. Judicious adjustment of crystallization conditions enabled the isolation of either polymeric or macrocyclic aggregates.

Comparison of Bovine Mammary Involution and Intramammary Infections Following Intramammary Treatment with Casein Hydrolysate and Other Conventional Treatments at Dry-Off.

Alternatives to routine antibiotic treatment of dairy cattle during the dry period before their next calving are of interest. This was a preliminary study of whether intramammary infusion of casein hydrolysate, administered alone or combined with standard dry treatment, accelerated the rate of mammary involution early in the dry period. Four treatments were studied in a split udder design.

Competing Effects of Chlorination on the Strength of Te⋅⋅⋅O Chalcogen Bonds Select the Structure of Mixed Supramolecular Macrocyclic Aggregates of Iso-Tellurazole N-Oxides.

Chlorination of 3-methyl-5-phenyl-1,2-tellurazole-2-oxide yielded the λ Te dichloro derivative. Its crystal structure demonstrates that the heterocycle retains its ability to autoassociate by chalcogen bonding (ChB) forming macrocyclic tetramers. The corresponding Te⋅⋅⋅O ChB distances are 2.

Graphite to diamond transition induced by photoelectric absorption of ultraviolet photons.

The phase transition from graphite to diamond is an appealing object of study because of many fundamental and also, practical reasons. The out-of-plane distortions required for the transition are a good tool to understand the collective behaviour of layered materials (graphene, graphite) and the van der Waals forces. As today, two basic processes have been successfully tested to drive this transition: strong shocks and high energy femtolaser excitation.

Cross-talk between Janus kinase-signal transducer and activator of transcription pathway and transforming growth factor beta pathways and increased collagen1A1 production in uterine leiomyoma cells.

Objective: To characterize the potential interaction between interleukin-6 (IL6), Janus kinase (JAK)-signal transducer and activator of transcription (STAT)-3 (JAK/STAT3) pathway, and Transforming growth factor beta (TGFβ)-3 , and to determine whether such cross-talk was a contributing factor in the dysregulation of type I collagen production in leiomyomas.

Design: Laboratory study.

Setting: University research laboratory.

Characterization of the role of Activator Protein 1 signaling pathway on extracellular matrix deposition in uterine leiomyoma.

Objective: To characterize the role Activator Protein 1 (AP 1) family members play in mediating extracellular matrix deposition in uterine leiomyoma.

Design: Laboratory study.

Setting: University research laboratory.

Reactions of [(dmpe)MnH(CH)]: synthesis and characterization of manganese(i) borohydride and hydride complexes.

Reactions of trans-[(dmpe)MnH(CH)] (1) with BH(NMe), 9-BBN, and HBMes yielded the manganese(i) borohydride complexes [(dmpe)Mn(μ-H)BR] (3: R = H, 4: R = CH, 5: R = Mes). The reaction of 1 with BH(NMe) proceeds via ethylene substitution. By contrast, a detuerium labelling study indicates that the reaction of 1 with HBMes involves initial isomerization of 1 to an unobserved 5-coordinate ethyl intermediate, [(dmpe)MnEt], which reacts with the hydroborane to afford EtBR and [(dmpe)MnH], followed by reaction with a second equivalent of hydroborane to generate 5 (an analogous pathway is likely followed for other base-free hydroboranes such as 9-BBN).