Publications by authors named "Brittany Ozar"
Plants belonging to the genus Nepenthes are carnivorous, using specialized pitfall traps called "pitchers" that attract, capture, and digest insects as a primary source of nutrients. We have used RNA sequencing to generate a cDNA library from the Nepenthes pitchers and applied it to mass spectrometry-based identification of the enzymes secreted into the pitcher fluid using a nonspecific digestion strategy superior to trypsin in this application. This first complete catalog of the pitcher fluid subproteome includes enzymes across a variety of functional classes.
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- Short contiguous peptide minimotifs can impact human variation and are influenced by selection, often showing a high level of conservation with 94% invariance.
- Analysis of approximately 300,000 minimotifs in nearly 1,100 human genomes revealed that most minimotifs are under negative selection, with some experiencing neutral drift or positive selection similar to coding regions.
- The study suggests minimotifs contribute to genetic variation, potentially affect DNA packaging due to variations in histone tails, and indicate adaptive evolution across different human populations.