Publications by authors named "Brittany N Vandenberg"
Article Synopsis
- UV light mainly causes C > T mutations in certain DNA sequences, but melanoma driver mutations often involve different changes like T > A, T > C, and C > A, which are not well understood in relation to UV exposure.
- Through experiments with yeast exposed to UVB and UVA light, researchers found that UVB mainly induces C > T, T > C, and T > A mutations, while UVA results in fewer mutations with a distinct pattern predominantly featuring C > A/G > T substitutions linked to oxidative damage.
- The study suggests that both UVB and UVA exposure can contribute to the noncanonical mutations associated with melanoma, with specific mechanisms and patterns underlying the mutations arising from each type of UV light.
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that could respectively cause BRAF V600K and V600E oncogenic mutations. The mutagenic bypass mechanism past these atypical lesions, however, is unknown.
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