Adolescent and young adult women's misunderstanding of the term Pap smear.

Objective: To learn more about young women's understanding of the term Pap smear.

Design: Self-administered survey.

Setting: UMass Memorial Adolescent Clinic.

Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter.

The cytochrome P450 4F3 (CYP4F3) gene encodes two functionally distinct enzymes that differ only by the selection of exon 4 (CYP4F3A) or exon 3 (CYP4F3B). CYP4F3A inactivates leukotriene B4, a reaction that has significance for controlling inflammation. CYP4F3B converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a potent activator of protein kinase C.

Membrane localization and topology of leukotriene C4 synthase.

Leukotriene C(4) (LTC(4)) synthase conjugates LTA(4) with GSH to form LTC(4). Determining the site of LTC(4) synthesis and the topology of LTC(4) synthase may uncover unappreciated intracellular roles for LTC(4), as well as how LTC(4) is transferred to its export carrier, the multidrug resistance protein-1. We have determined the membrane localization of LTC(4) synthase by immunoelectron microscopy.