Publications by authors named "Brittany Laslow"
Article Synopsis
- Estrogen deficiency contributes to conditions like primary ovarian insufficiency and postmenopausal osteoporosis, disrupting the balance of bone formation and resorption, leading to bone loss and a higher risk of fractures due to reduced trabecular bone mass.
- In the bone marrow, hypoxia-inducible factor-2α (HIF2) is vital for cell responses to low-oxygen conditions, and its loss in skeletal progenitors enhances trabecular bone mass by boosting bone formation.
- The study shows that PT2399, a HIF2 inhibitor, can prevent bone loss in estrogen-deficient mice by increasing the number of osteoblasts and expanding the skeletal progenitor cell pool, highlighting a key mechanism for bone formation and mass
Energy metabolism, through pathways such as oxidative phosphorylation (OxPhos) and glycolysis, plays a pivotal role in cellular differentiation and function. Our study investigates the impact of OxPhos disruption in cortical bone development by deleting mitochondrial transcription factor A (TFAM). TFAM controls OxPhos by regulating the transcription of mitochondrial genes.
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