Base of tongue neuroendocrine carcinoma: A case report.

Neuroendocrine tumors are rare entities in the head and neck and an even more rare entity in the tongue. In this case report, we describe a calcified neuroendocrine tumor of the base of tongue that was presumed to be benign and was electively excised with pathology demonstrating low-grade carcinoma with focal neuroendocrine features and extensive ossification. We then discuss the histopathology and management.

Blastocyst development after fertilization with in vitro spermatids derived from nonhuman primate embryonic stem cells.

Objective: To demonstrate that functional spermatids can be derived in vitro from nonhuman primate pluripotent stem cells.

Design: Green fluorescent protein-labeled, rhesus macaque nonhuman primate embryonic stem cells (nhpESCs) were differentiated into advanced male germ cell lineages using a modified serum-free spermatogonial stem cell culture medium. In vitro-derived round spermatid-like cells (rSLCs) from differentiated nhpESCs were assessed for their ability to fertilize rhesus oocytes by intracytoplasmic sperm(atid) injection.

Sinonasal Anatomic Variants in Allergic Fungal Rhinosinusitis.

Background: The pathophysiology of allergic fungal rhinosinusitis (AFRS) is not well understood.

Objectives: To study the incidence of sinonasal anatomic variants (AVs) in AFRS.

Methods: Retrospective cohort study.

Subjective and Objective Measurements of Sinonasal Manifestations in Patients With Autoimmune Disorders.

Objectives/hypothesis: A number of autoimmune disorders (ADs) are associated with a spectrum of sinonasal manifestations comparable to chronic rhinosinusitis (CRS). Our objective was to study the subjective and objective measurements of sinonasal manifestations of ADs.

Study Design: Retrospective cohort study.

Per- and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model.

Unlabelled: Per- and polyfluoroalkyl substances (PFASs) represent a highly ubiquitous group of synthetic chemicals used in products ranging from water and oil repellents and lubricants to firefighting foam. These substances can enter and accumulate in multiple tissue matrices in up to 100% of people assessed. Though animal models strongly identify these compounds as male reproductive toxicants, with exposed rodents experiencing declines in sperm count, alterations in hormones, and DNA damage in spermatids, among other adverse outcomes, human studies report conflicting conclusions as to the reproductive toxicity of these chemicals.

Ubiquitous Flame-Retardant Toxicants Impair Spermatogenesis in a Human Stem Cell Model.

Sperm counts have rapidly declined in Western males over the past four decades. This rapid decline remains largely unexplained, but exposure to environmental toxicants provides one potential explanation for this decline. Flame retardants are highly prevalent and persistent in the environment, but many have not been assessed for their effects on human spermatogenesis.