Publications by authors named "Brittany Cordova"
Hematopoietic stem cells (HSCs) adapt to organismal blood production needs by balancing self-renewal and differentiation, adjusting to physiological demands and external stimuli. Although sex differences have been implicated in differential hematopoietic function in males versus females, the mediators responsible for these effects require further study. Here, we characterized hematopoiesis at a steady state and during regeneration following hematopoietic stem cell transplantation (HST).
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- Exportin-1 (XPO1) is crucial for transporting proteins from the nucleus to the cytoplasm and also plays a role in processes like centrosome duplication; it is targeted by small molecules for cancer treatment, notably selinexor for multiple myeloma.
- Research highlights a cell-type-dependent function of XPO1 in binding to chromatin, which is vital for the activity of NFAT transcription factors and proper T cell activation.
- A new class of XPO1-targeting small molecules has been developed that disrupt XPO1's chromatin binding specifically, providing a potential therapeutic avenue for treating T cell-driven autoimmune disorders without causing cell death.
Amblypygids use a pair of modified walking legs (antenniform) as chemosensory and mechanosensory appendages. At the tip of these legs are covered in chemosensory sensilla, which the animals use to sample odor stimuli in their environment by moving the antenniform leg through the air. We designed a set of experiments to measure the filtering effect that aerodynamic boundary layers have on the temporal and spatial structure of chemical stimuli.
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